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Cell and molecular biomechanics: perspectives and challenges

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Abstract

As an intriguing interdisciplinary research field, cell and molecular biomechanics is at the cutting edge of mechanics in general and biomechanics in particular. It has the potential to provide a quantitative understanding of how forces and deformation at tissue, cellular and molecular levels affect human health and disease. In this article, we review the recent advances in cell and molecular biomechanics, examine the available computational and experimental tools, and discuss important issues including protein deformation in mechanotransduction, cell deformation and constitutive behavior, cell adhesion and migration, and the associated models and theories. The opportunities and challenges in cell and molecular biomechanics are also discussed. We hope to provide readers a clear picture of the current status of this field, and to stimulate a broader interest in the applied mechanics community.

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Authors and Affiliations

  1. Department of Applied Mechanics, Beijing Institute of Technology, Beijing, 100081, China

    Baohua Ji

  2. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA

    Gang Bao

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  1. Baohua Ji
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Ji, B., Bao, G. Cell and molecular biomechanics: perspectives and challenges. Acta Mech. Solida Sin. 24, 27–51 (2011). https://doi.org/10.1016/S0894-9166(11)60008-6

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