Propolis is a natural, non-toxic resin produced by honey bees that has been used for hundreds of years for its biological activities, such as antimicrobial, anti-inflammatory, anesthetic, cytostatic, and cariostatic properties. Currently, it is used in food, pharmaceutical, and cosmetic industries. The aim of this work was to evaluate the antioxidant activity, sun protection factor, and photostability of different hydroalcoholic extracts of green propolis. All extracts prepared presented high absorption in the UVB region. The extract of 70% green propolis (high temperature) was incorporated into Gel Permulen TR-1. This new formulation presented a higher value of sun protection factor. Besides that, the formulation developed with Gel Permulen TR-1 and the hydroalcoholic extract of 70% green propolis (high temperature) showed good photostability and it was safe to be applied on the skin according the HET-CAM test. These results indicated the potential of hydroalcoholic extracts of 70% green propolis (high temperature) for use in sunscreen.
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The authors would like to thank the Departamento de Química and Escola de Farmácia da Universidade Federal de Ouro Preto and Núcleo de Pesquisa de Produtos Naturais e Sintéticos da Universidade de São Paulo, Ribeirão Preto.
This study was financially supported by PROPP/UFOP (No. 23109.004080/2019-88).
Conflict of Interest
The authors declare that they have no conflict of interest.
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Almeida, W.A.d., Sousa, L.R.D., dos Santos Antunes, A. et al. Green Propolis: In Vitro Photoprotective and Photostability Studies of Single and Incorporated Extracts in a Sunscreen Formulation. Rev. Bras. Farmacogn. 30, 436–443 (2020). https://doi.org/10.1007/s43450-020-00071-z
- Sun protection factor
- Antioxidant activity