Endometrial Organoids: A Rising Star for Research on Endometrial Development and Associated Diseases

Abstract

The endometrium is one of the most dynamic organs in the human body. Until now, cell lines have furthered the understanding of endometrial biology and associated diseases, but they failed to recapitulate the key physiological aspects of the endometrium, especially as it relates to its complex architecture and functions. Organoid culture systems have become an alternative approach to reproduce biological functions of tissues in vitro. Endometrial organoids have now been established from stem/progenitor cells and/or differentiated cells by several methods, which represents a promising tool to gain a deeper understanding of this dynamic organ. In this review, we will discuss the establishment, characteristics, applications, and potential challenges and directions of endometrial organoids.

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Acknowledgments

This study was funded by NIH Grants R01 HD042280 and HD083273 to A.T.F.

Funding

This research was supported by NIH grants RO1 HD042280 and HD083273 to A.T.F.

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Correspondence to Asgerally T. Fazleabas.

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Song, Y., Fazleabas, A.T. Endometrial Organoids: A Rising Star for Research on Endometrial Development and Associated Diseases. Reprod. Sci. (2021). https://doi.org/10.1007/s43032-021-00471-z

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Keywords

  • Endometrial organoid
  • Endometrium
  • Endometrial development
  • Endometriosis
  • Endometrial cancer
  • Polycystic ovary syndrome