Corticosteroids in Pregnancy for Preventing RDS: Overview of Systematic Reviews

Abstract

The objective of this study was to analyze the available evidence of systematic reviews that evaluated the efficacy of antenatal corticosteroids in order to contribute to a reduction in magnitude and transcendence of respiratory distress syndrome of the newborn (RDS). Thus, an overview was conducted including all systematic reviews of randomized controlled trials (RCTs) that evaluated women who received corticosteroid treatment during pregnancy to prevent RDS. Therefore, a search strategy was developed using the terms “respiratory distress syndrome, newborn,” “corticosteroids,” “perinatal death,” “neonatal death,” “neonate,” and “pregnancy.” The electronic databases searched were MEDLINE, EMBASE, Cochrane Library, LILACS, and Google Scholar, for studies published until June 2020. We identified 354 references, 38 of which were relevant after the initial screening. Ten systematic reviews met the inclusion criteria. For RDS, 1522 cases occurred in the control group composed of 8716 participants, while in the intervention group was 1088 in 8740 participants (RR = 0.67, 95% CI 0.60–0.75). For neonatal death, 343 cases occurred in 5248 participants of the control group, while in the intervention group, there were 227 cases in 5246 participants (RR = 0.66, 95% CI 0.56–0.78). For perinatal death, there were 344 cases in 3345 participants in the control group, while in the intervention group, the number of cases was 264 in 3384 participants (RR = 0.72, 95% CI 0.58–0.89). Thus, the use of corticosteroids during pregnancy in women at risk of preterm birth is effective for the prevention of RDS in neonates and reducing the number of neonatal and perinatal deaths in preterm. PROSPERO protocol no: CRD42017074604

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MLR Uggioni: Protocol/project development, data collection and management, data analysis, statistical analysis, and manuscript writing/editing. T Colonetti: Data collection or management, data analysis, and manuscript writing/editing. AJ Grande: Data collection or management, data analysis, and manuscript writing/editing. MVB Cruz: Manuscript writing/editing. MI Rosa: Protocol/project development, data collection or management, data analysis, statistical analysis, and manuscript writing/editing.

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Correspondence to Maria Laura Rodrigues Uggioni.

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Uggioni, M.L.R., Colonetti, T., Grande, A.J. et al. Corticosteroids in Pregnancy for Preventing RDS: Overview of Systematic Reviews. Reprod. Sci. (2021). https://doi.org/10.1007/s43032-020-00425-x

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Keywords

  • Respiratory distress syndrome, newborn
  • Corticosteroids
  • Perinatal death
  • Neonatal death