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Structural and Interfacial Effects on Drug Release Kinetics of Liquid-Based Fibrous Catheter

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Abstract

Catheterization is indispensable in the field of modern medicine. However, catheter-related thrombosis and infections almost inevitably occur during the process, and as drugs can only be administered at the end of catheter, auxiliary strategies are required for successful implantation. Considering these intractable limitations, a type of self-adaptive, anti-coagulate liquid-based fibrous catheter has been developed. More importantly, it has positional drug release property that traditional catheters desperately need but couldn’t attain. Although enlightening, the feasibility and performance of the positional drug release have only been demonstrated by fluorescents, the specific drug release kinetics remains unknown for adaptation to application scenarios. Therefore, we systematically investigate the structural and interfacial effects of drug molecules and fibrous matrixes on drug release kinetics in a liquid-based fibrous catheter. Theoretical calculations and experiments demonstrate that oleophilic and hydrophilic molecules release slowly due to a dissolution-diffusion mechanism. Amphipathic molecules, however, will significantly affect the gating performance by affecting the interfacial stability, hence they release quickly with emulsifying the gating liquid. Besides the significant impact of molecular properties and interfacial effects, matrix pore size also has a slight influence that molecules release faster in bigger pores. Through this study, the liquid-based fibrous catheter may step further toward practical applications including chemotherapy, haemodialysis, angiography, etc. to overcome the existing catheter-related limitations.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (52025132, 21975209, 21621091, 22021001, 22121001), the National Key R&D Program of China (2018YFA0209500), the National Science Foundation of Fujian Province of China (2022J02059), the Fundamental Research Funds for the Central Universities of China (20720220085), the 111 Project (B17027, B16029), the Science and Technology Projects of Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (RD2022070601), and the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS (No: NSKF202008).

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  1. Chunyan Wang and Yaqi Hou contributed equally to the work.

Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, China

    Chunyan Wang, Yaqi Hou, Xingyi Wang, Weijun Li, Yunmao Zhang, Shuli Wang, Jing Zheng & Xu Hou

  2. Collaborative Innovation Center of Chemistry for Energy Materials, Xiamen University, Xiamen, 361005, China

    Chunyan Wang, Shuli Wang & Xu Hou

  3. Department of Electronic Science, Fujian Engineering Research Center for Solid-State Lighting, School of Electronic Science and Engineering, Xiamen University, Xiamen, 361005, China

    Shuli Wang

  4. College of Physical Science and Technology, Xiamen University, Xiamen, 361005, China

    Xu Hou

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  1. Chunyan Wang
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Wang, C., Hou, Y., Wang, X. et al. Structural and Interfacial Effects on Drug Release Kinetics of Liquid-Based Fibrous Catheter. Adv. Fiber Mater. 4, 1645–1655 (2022). https://doi.org/10.1007/s42765-022-00201-3

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