Skip to main content

Advertisement

SpringerLink
Log in

Interventricular Septal Cardiac Metastasis from Transitional Cell Carcinoma of Bladder: a Case Report with Review of Literature

  • Case Report
  • Published:
SN Comprehensive Clinical Medicine Aims and scope Submit manuscript

Abstract

Synchronous cardiac metastasis from transitional cell carcinoma of bladder is extremely rare. Almost all reported cases in the literature showed metachronous cardiac metastases. The prognosis of patients with cardiac metastases is extremely poor with survival ranging from a few days to months. We report a case of synchronous interventricular septal cardiac metastasis from transitional cell carcinoma of bladder treated with platinum-based palliative chemotherapy and had a lethal outcome. Diagnosis of synchronous cardiac metastasis from transitional cell carcinoma of bladder is extremely rare and shows a poor prognosis even after palliative chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data Availability

The patient’s medical file is available in PGIMER; Chandigarh. Dr. Kannan Periasamy has got full access to the medical records of the patient and can be made available on request.

Code Availability

Not applicable.

Abbreviations

CT:

computed tomography

PET:

positron emission tomography

FDG:

fluoro-deoxy glucose

ECOG-PS:

Eastern Cooperative Oncology Group Performance Status

References

  1. Lam KY, Dickens P, Chan AC. Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med. 1993;117(10):1027–31.

    CAS  PubMed  Google Scholar 

  2. Babaian RJ, Johnson DE, Llamas L, Ayala AG. Metastases from transitional cell carcinoma of urinary bladder. Urology. 1980;16(2):142–4.

    Article  CAS  PubMed  Google Scholar 

  3. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60(1):27–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Glancy DL, Roberts WC. The heart in malignant melanoma. Am J Cardiol. 1968;21(4):555–71.

    Article  CAS  PubMed  Google Scholar 

  5. Clemente LM, Patier JL, Lopez-Suanzes MJ, Jimenez M. Cardiac metastases from a transitional cell carcinoma: an unusual clinical manifestation. BJU Int. 1997;80(5):831–2.

    Article  CAS  Google Scholar 

  6. Doshi TV, Doshi JV, Makaryus JN, Makaryus AN. A rare case of successfully treated cardiac metastasis from transitional cell bladder cancer. Am J Ther. 2013;20(3):307–10.

    Article  PubMed  Google Scholar 

  7. Fabozzi SJ, Newton JR Jr, Moriarty RP, Schellhammer PF. Malignant pericardial effusion as initial solitary site of metastasis from transitional cell carcinoma of the bladder. Urology. 1995;45(2):320–2.

    Article  CAS  PubMed  Google Scholar 

  8. Gorospe L, García-Santana E, Jane-Soler P, Gómez-Martínez MDV, Gómez-Dos-Santos V, García-Gómez-Muriel I, et al. Cardiac and skeletal muscle metastases from squamous cell carcinoma of the bladder: positron emission tomography-computed tomography findings. Urology. 2017;100:e5–6.

    Article  PubMed  Google Scholar 

  9. Kamakura M, Okazaki A, Ito K, Kin F, Miyajima K, Takashima Y, et al. Concomitant pulmonary and cerebral tumor embolism and intracardiac metastasis from bladder cancer. Intern Med Tokyo Jpn. 2021;60(23):3749–53.

    Article  Google Scholar 

  10. Kemp W, Rothberg M, Saporito JJ, Bergstrom I. Transitional cell carcinoma and right ventricular obstruction. The Journal of urology. 1997;158(4):1522–3.

    Article  CAS  PubMed  Google Scholar 

  11. Khan R, Jehangir W, Tulpule S, Osman M, Singh S, Sen S. Pericardial metastasis induced tamponade from urothelial carcinoma: a rare entity. Case Rep Med. 2016;2016:e6162732.

    Article  Google Scholar 

  12. Lin W-C, Telen M. Cardiac metastasis from a transitional cell carcinoma: a case report. Med Oncol. 2000;17(2):147–50.

    Article  CAS  PubMed  Google Scholar 

  13. Malde DJ, Gall Z, George N. Ventricular rupture secondary to cardiac metastasis of transitional cell carcinoma of the bladder. Scand J Urol Nephrol. 2006;40(2):170–1.

    Article  CAS  PubMed  Google Scholar 

  14. Mountzios G, Bamias A, Dalianis A, Danias P, Pantelidaki E, Nanas J, et al. Endocardial metastases as the only site of relapse in a patient with bladder carcinoma: a case report and review of the literature. Int J Cardiol. 2010;140(1):e4–7.

    Article  CAS  PubMed  Google Scholar 

  15. Na JO, Choi CU, Lim HE. Cardiac metastasis of bladder cancer presented as mimicking ST-segment elevation myocardial infarction. Eur Heart J. 2011;32(1):40.

    Article  PubMed  Google Scholar 

  16. Palam S, Kapoor R, Kulinski J. A rare presentation of cardiac tamponade from metastatic urothelial carcinoma of the bladder. Case Rep Cardiol. 2018;2018:e6750264.

    Google Scholar 

  17. Peck JR, Hitchcock CL, Maguire S, Dickerson J, Bush C. Isolated cardiac metastasis from plasmacytoid urothelial carcinoma of the bladder. Exp Hematol Oncol. 2012;1(1):16.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Spiliotopoulos K, Argiriou M, Argyrakos T, Haritopoulos K, Kanakakis K, Sakellaridis T, et al. Solitary metastasis of urothelial carcinoma of the urinary bladder to the heart: An unusual clinical manifestation. J Thorac Cardiovasc Surg. 2008;136(5):1377–1378.e1.

    Article  PubMed  Google Scholar 

  19. Zanchettin C, Zanella L, Zoffoli G, Venturini A, Gallingani A, Ronco F, et al. Ultra-rapid regrowth of urothelial cardiac metastasis after debulking surgery. Cardiovasc Pathol. 2021;53:107334.

    Article  PubMed  Google Scholar 

  20. Soubra A, Hayward D, Dahm P, Goldfarb R, Froehlich J, Jha G, et al. The diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography and computed tomography in staging bladder cancer: a single-institution study and a systematic review with meta-analysis. World J Urol. 2016;34(9):1229–37.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiotherapy and Oncology, PGIMER, Chandigarh, 160012, India

    Kannan Periasamy, Vigneshwaran Chandran, Shikha Goyal & Karthick Raja

  2. Department of Urology, Advanced Urology Centre, PGIMER, Chandigarh, India

    Sudheer Kumar Devana & Santosh Kumar

  3. Department of Nuclear Medicine, PGIMER, Chandigarh, India

    Rajender Kumar Basher

Authors
  1. Kannan Periasamy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vigneshwaran Chandran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shikha Goyal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sudheer Kumar Devana
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Santosh Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rajender Kumar Basher
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Karthick Raja
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

KP has made substantial contribution in treating the patient and writing the initial manuscript and finalising the modified version. SG, SD, and SK have made significant contributions in treating the patient and critically analysing the manuscript. VC and KR have contributed significantly in analysing and submitting the manuscript. RK has made a significant contribution to the manuscript by providing the PET-CT images.

Corresponding author

Correspondence to Kannan Periasamy.

Ethics declarations

Ethical Approval and Consent to Participate

Not required for case report by our institution.

Consent for Publication

Written informed consent for publication has been obtained.

Competing Interests

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Imaging

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Periasamy, K., Chandran, V., Goyal, S. et al. Interventricular Septal Cardiac Metastasis from Transitional Cell Carcinoma of Bladder: a Case Report with Review of Literature. SN Compr. Clin. Med. 5, 228 (2023). https://doi.org/10.1007/s42399-023-01572-3

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s42399-023-01572-3

Keywords

Search

Navigation