Ankle osteoarthritis is mostly post-traumatic and in young people. Autologous fat cells have been successfully used to treat hip and knee OA. Aim of this study is to evaluate the efficacy of autologous microfragmented fat cell therapy in ankle osteoarthritis. This paper reports a 39-year-old labourer with post-traumatic advanced osteoarthritis of the ankle who was given Lipogem treatment. After lipoaspiration from the abdomen, processing and injection of microfragmented adipose tissue into the ankle was done. Patient was assessed for visual analogue scale (VAS), Manchester-Oxford Foot Questionnaire (MOXFQ) scores and Foot and Ankle Ability Measure (FAAM) scores preoperatively and at 6 months after treatment. There was considerable improvement in all patient-reported outcome measures at 6 months follow-up with no complications. Microfragmented adipose cell therapy for end-stage ankle arthritis can delay need for ankle fusion or replacement in young patients.
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Brown TD, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006;20(10):739–44. https://doi.org/10.1097/01.bot.0000246468.80635.ef.
Freitag J, Bates D, Wickham J, Shah K, Huguenin L, Tenen A, et al. Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial. Regen Med. 2019;14:213–30. https://doi.org/10.2217/rme-2018-0161.
Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279–95. https://doi.org/10.1091/mbc.E02-02-0105.
Lopa S, Colombini A, Moretti M, de Girolamo L. Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences. Knee Surg Sports Traumatol Arthrosc. 2018;27:2003–20. https://doi.org/10.1007/s00167-018-5118-9.
Tremolada C, Colombo V, Ventura C. Adipose tissue and mesenchymal stem cells: state of the art and Lipogems® technology development. Curr Stem Cell Rep. 2016;2(3):304–12. https://doi.org/10.1007/s40778-016-0053-5.
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Niazi, N., Islam, A., Aljawadi, A. et al. Autologous Micro Fragmented Adipose Cell Therapy for End-Stage Ankle Osteoarthritis—Case Report and Review of Literature. SN Compr. Clin. Med. (2021). https://doi.org/10.1007/s42399-021-00753-2
- Ankle osteoarthritis
- Microfragmented fat cells
- Stem cells