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Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review

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Abstract

Insulinoma is the most common functioning pancreatic neuroendocrine tumor with the development of the organic hyperinsulinism and the severe hypoglycemia. Insulinoma can be treated radically only by surgical removal. In cases when the surgery may cause severe complications with the high risk of mortality, the physical non-surgical methods can be used. The world literature review using PubMed, MedScape, and Cochrane databases was performed. Keywords “insulinoma” + “physical methods” were used including every type of the method. One hundred fifty-two articles in English devoted to different physical methods of treatment of neuroendocrine tumors were found. Twenty-seven papers with the description of the minimally invasive treatment of insulinomas were found among them. There were data about the different methods revealed such as radiofrequency ablation, microwave ablation, cryodestruction, laser ablation, irreversible electroporation, photodynamic therapy, high-intensity focused ultrasound, Cyberknife, and tumor alcoholization. Literature search showed that there are a few papers about the description of the self-experience of each method, but there are no papers with the full compartment of advantages and disadvantages of each method of treatment. Each method was used because of its availability in the hospital or department. Contemporary statement of the physical mini-invasive method of insulinomas treatment requires investigations with the full randomized trials. These researches can identify the points to use one or another physical method and to choose the most right way to treat patients with hormonal-producing pancreatic neuroendocrine tumors.

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Authors and Affiliations

  1. A.V. Vishnevsky Institute of Surgery, Ministry of Health, Russia, 27 B Serpuhovskaja Street, Moscow, Russian Federation, 115093

    Stanislav V. Berelavichus, Andrey G. Kriger, Rimma S. Dugarova & Ayrat R. Kaldarov

  2. Abdominal Surgery Department, A.V. Vishnevsky Institute of Surgery, 16/1 Solov’iny Proezd 139, Moscow, Russian Federation, 117593

    Stanislav V. Berelavichus

  3. Abdominal Surgery Department, A.V. Vishnevsky Institute of Surgery, 5 Universitetsky Prospekt 289, Moscow, Russian Federation, 119296

    Andrey G. Kriger

  4. Abdominal Surgery Department, A.V. Vishnevsky Institute of Surgery, 40, Skobelevskaja street 70, Moscow, Russian Federation, 117624

    Rimma S. Dugarova

  5. Abdominal Surgery Department, A.V. Vishnevsky Institute of Surgery, 9, Novoe Shosse 78, Drojjino, Moscow Region, Russian Federation, 142718

    Ayrat R. Kaldarov

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  1. Stanislav V. Berelavichus
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Correspondence to Ayrat R. Kaldarov.

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Berelavichus, S.V., Kriger, A.G., Dugarova, R.S. et al. Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review. SN Compr. Clin. Med. 1, 104–112 (2019). https://doi.org/10.1007/s42399-018-0024-5

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