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Three-dimensional bioprinting of gelatin methacryloyl (GelMA)

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Abstract

The three-dimensional (3D) bioprinting technology has progressed tremendously over the past decade. By controlling the size, shape, and architecture of the bioprinted constructs, 3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural–functional similarity with their in vivo counterparts at high fidelity. The bioink, a blend of biomaterials and living cells possessing both high biocompatibility and printability, is a critical component of bioprinting. In particular, gelatin methacryloyl (GelMA) has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical properties. Current GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed.

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Acknowledgements

The authors gratefully acknowledge funding from the National Institutes of Health (K99CA201603, R21EB025270, R21EB026175) and Doctoral New Investigator Grant from American Chemical Society Petroleum Research Fund (56840-DNI7). G. L. Y. acknowledges Natural and Science Foundation of Hubei Province (2014CFB778).

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Author notes

  1. Guoliang Ying and Nan Jiang have contributed equally to this work.

Authors and Affiliations

  1. Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, 02139, USA

    Guoliang Ying & Yu Shrike Zhang

  2. School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, People’s Republic of China

    Guoliang Ying

  3. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02139, USA

    Nan Jiang

  4. Departments of Mechanical Engineering, Electrical and Computer Engineering, Biomedical Engineering, Materials Science and Engineering Program, The Texas Center for Superconductivity, University of Houston, Houston, TX, 77204, USA

    Cunjiang Yu

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  1. Guoliang Ying
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Correspondence to Cunjiang Yu or Yu Shrike Zhang.

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Ying, G., Jiang, N., Yu, C. et al. Three-dimensional bioprinting of gelatin methacryloyl (GelMA). Bio-des. Manuf. 1, 215–224 (2018). https://doi.org/10.1007/s42242-018-0028-8

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