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Deutsche Zeitschrift für Akupunktur

, Volume 61, Issue 2, pp 78–79 | Cite as

Arzneimittelsicherheit von Lokalanästhetika

  • Heidemarie Haller
Journal Club

Abstract

Originalpublikation

Weinschenk S, Mergenthaler C, Armstrong C, Göllner R, Hollmann MW, Strowitzki T (2017) Local anesthetics, procaine, lidocaine, and mepivacaine show vasodilatation but no type 1 allergy: a double-blind, placebo-controlled study. BioMed Research International.  https://doi.org/10.1155/2017/9804693

Background

Therapy with local anesthetics (LAs), also known as neural therapy, is used in integrative medicine because of its anti-inflammatory properties. Ester-linked LAs are often avoided because of their alleged high allergenicity. Little data supports this assumption and hence the importance of our investigation on type-1 allergies against ester- and amide-linked LAs. We performed a prospective, double-blinded, placebo-controlled observational study.

Methods

177 patients received 340 intracutaneous injections with 1 % procaine, 0.5 % lidocaine, 1 % mepivacaine, or saline solution. Every patient received two different tests on each forearm. Reactions were...

Drug safety of local anesthetics

Notes

Interessenkonflikt

H. Haller gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Jacob JS, Kovac AL (2017) Procaine and local anesthetic toxicity: a collaboration between the clinical and basic sciences. Reg Anesth Pain Med 42(6):760–763CrossRefPubMedGoogle Scholar
  2. 2.
    Hahn-Godeffroy JD (2014) Zur Unentbehrlichkeit von Procain in der Neuraltherapie. Dtsch Z Akupunktur 57(4):30CrossRefGoogle Scholar
  3. 3.
    Hahn-Godeffroy JD (2011) Zur Arzneimittelsicherheit von Procain. Dtsch Z Akupunktur 54(4):28–29CrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Klinik für Naturheilkunde und Integrative Medizin, Kliniken Essen-Mitte, Medizinische FakultätUniversität Duisburg-EssenEssenDeutschland

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