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Redesigning the modern applied medical sciences and engineering with shape memory polymers

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Abstract

The shape memory polymers (SMPs) are one of the most evolved classes of stimuli-responsive polymers that can attain a temporary shape and retrace back to the original shape when excited with a stimulus. The advantages of these materials being lightweight and possessing high strain recovery ability make them one of the most vogue materials in the realms of applied medical sciences. The following perspective is an author’s reflection on how these materials have evolved since its inception. Moreover, the article revisits some of the growing trends in the area of these smart materials, touching upon the latest developments, such as 4D printed SMPs. In an attempt to blend both the applications and the technology, the perspective provides a succinct overview of the expanding boundaries of the SMPs employed to fabricate medical devices.

Graphical abstract

To illustrate the versatility of shape morphing polymers in the applied medical sciences and biomedicine including vascular, orthopedic, and neuronal applications

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copyright reserved MDPI, 2013

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copyright reserved Science, 2002

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copyright reserved American Chemical Society 2016. (Bottom) Illustration of removal of a clot in a blood vessel using the laser-activated shape memory polymer microactuator coupled to an optical fiber, reproduced with permission from [28], copyright reserved Elsevier 2007

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copyright reserved American Chemical Society 2014

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copyright reserved BioMedical Engineering OnLine 2007

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copyright reserved Springer, 2020

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References

  1. Chitwood WR, Elbeery JR, Moran JF (1997) Minimally invasive mitral valve repair using transthoracic aortic occlusion. Ann Thorac Surg 63(5):1477–1479. https://doi.org/10.1016/s0003-4975(97)00242-7

    Article  Google Scholar 

  2. Basak S (2020) The age of multistimuli-responsive nanogels: the finest evolved nano delivery system in biomedical sciences. Biotechnol Bioproc E 25:655–669. https://doi.org/10.1007/s12257-020-0152-0

    Article  CAS  Google Scholar 

  3. Wang K, Strandman S, Zhu X (2017) A mini review: Shape memory polymers for biomedical applications. Front Chem Sci Eng 11. https://doi.org/10.1007/s11705-017-1632-4

  4. Strzelec K, Sienkiewicz N, Szmechtyk T (2020) Classification of shape-memory polymers, polymer blends, and composites. In: Parameswaranpillai J, Siengchin S, George J, Jose S (eds) Shape Memory Polymers, Blends and Composites. Advanced Structured Materials, vol 115. Springer, Singapore

  5. Rainer WC, Edward M, Redding JJ, Hitov AWS, William DS (1964) "Polyethylene product and process." U.S. Patent 3,144,398, issued August 11, 1964

  6. Peterson G, Dobrynin A, Becker M (2017) Biodegradable shape memory polymers in medicine. Adv Healthc Mater 6:1700694. https://doi.org/10.1002/adhm.201700694

    Article  CAS  Google Scholar 

  7. Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z (2018) Current development of biodegradable polymeric materials for biomedical applications. Drug Des Devel Ther 12:3117–3145. https://doi.org/10.2147/DDDT.S165440

    Article  CAS  Google Scholar 

  8. Lendlein A, Langer R (2002) Biodegradable, elastic shape-memory polymers for potential biomedical applications. Sci 296(5573):1673–1676. https://doi.org/10.1126/science.1066102

    Article  Google Scholar 

  9. Hardy J, Palma M, Shalom J, Biggs M (2016) Responsive biomaterials: advances in materials based on shape-memory polymers. Adv Mater (Deerfield Beach, Fla.). 28. https://doi.org/10.1002/adma.201505417

  10. Liu C, Qin H, Mather P (2007) Review of progress in shape-memory polymers. J Mater Chem. 17. https://doi.org/10.1039/b615954k

  11. Bowman C, Cramer N, Shandas R, Nair DP (2014) inventors; University of Colorado Boulder, assignee. Thiol-vinyl and thiol-yne systems for shape memory polymers. United States patent US 8,846,777. 2014 Sep 30

  12. Shandas R, Nelson A, Rech B, Nair DP, Lyons MB, Castleberry JP, Scott TF (2015) inventors; University of Colorado Boulder, assignee. Shape memory polymer prosthetic medical device. United States patent US 9,119,714. 2015 Sep 1

  13. Brown M, de Oca Balderas HM, Hall MA, Bull AW, Farrar DF, Caton-Rose P, Coates PD, Thompson G, Martyn M, Ward IM, Bonner MJ (2015) inventors. Shape memory polymer compositions. United States patent application US 14/350,037. 2015 Mar 12

  14. Hearon K, Wierzbicki MA, Nash LD, Landsman TL, Laramy C, Lonnecker AT, Gibbons MC, Ur S, Cardinal KO, Wilson TS, Wooley KL (2015) A processable shape memory polymer system for biomedical applications. Adv Healthc Mater 4(9):1386–1398

    Article  CAS  Google Scholar 

  15. Xie M, Wang L, Ge J, Guo B, Ma PX (2015) Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering. ACS Appl Mater Interfaces 7(12):6772–6781

    Article  CAS  Google Scholar 

  16. Zarek M, Mansour N, Shapira S, Cohn D (2017) 4D printing of shape memory-based personalized endoluminal medical devices. Macromol Rapid Commun 38(2):1600628

    Article  Google Scholar 

  17. Jia H, Gu SY, Chang K (2018) 3D printed self-expandable vascular stents from biodegradable shape memory polymer. Adv Polym Technol 37(8):3222–3228

    Article  CAS  Google Scholar 

  18. Herting SM, Ding Y, Boyle AJ, Dai D, Nash LD, Asnafi S, Jakaitis DR, Johnson CR, Graul LM, Yeh C, Kallmes DF (2019) In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model. J Biomed Mater Res B Appl Biomater 107(8):2466–2475

    Article  CAS  Google Scholar 

  19. Hiltz J (2002) Shape Memory Polymers. Lit Rev 36. https://doi.org/10.13140/2.1.1640.5281

  20. Hager MD, Bode S, Weber C, Schubert US (2015) Shape memory polymers: Past, present and future developments. Prog Polym Sci 49–50:3–33. https://doi.org/10.1016/j.progpolymsci.2015.04.002

    Article  CAS  Google Scholar 

  21. Wu X, Huang W, Zhao Y, Ding Z, Tang C, Zhang J (2013) Mechanisms of the shape memory effect in polymeric materials. Polym 5:1169–1202. https://doi.org/10.3390/polym5041169

    Article  CAS  Google Scholar 

  22. Cao L, Wang L, Zhou C, Hu X, Fang L, Ni Y, Lu C, Xu Z (2020) Surface structures, particles, and fibers of shape-memory polymers at micro-/nanoscale. Polym Adv Technol. 2020

  23. Sokolowski W, Metcalfe A, Hayashi S, Yahia L, Raymond J (2007) Medical applications of shape memory polymers. Biomed Mater (Bristol, England) 2:S23–S27. https://doi.org/10.1088/1748-6041/2/1/S04

    Article  CAS  Google Scholar 

  24. Santo L, Quadrini F, Bellisario D, Iorio L (2020) Applications of shape-memory polymers, and their blends and composites. InShape Memory Polymers, Blends and Composites 2020 (pp. 311–329). Springer, Singapore

  25. Wischke C, Neffe AT, Lendlein A (2009) Controlled drug release from biodegradable shape-memory polymers. In: Lendlein A. (eds) Shape-memory polymers. Advances in Polymer Science, vol 226. Springer, Berlin, Heidelberg

  26. Farber E, Zhu JN, Popovich A, Popovich V (2020) A review of NiTi shape memory alloy as a smart material produced by additive manufacturing. Materials Today: Proceedings. 2020 Feb 17

  27. Wei H, Zhang Q, Yao Y, Liu L, Liu Y, Jinsong L (2016) Direct-write fabrication of 4D active shape-changing structures based on a shape memory polymer and its nanocomposite. ACS Applied Materials & Interfaces. 9. https://doi.org/10.1021/acsami.6b12824

  28. Marc B, Andreas L (2007) Shape-memory polymers, Materials Today, Volume 10, Issue 4, 2007, Pages 20–28, ISSN 1369–7021, https://doi.org/10.1016/S1369-7021(07)70047-0

  29. Miyata T, Asami N, Uragami T (1999) A reversibly antigen-responsive hydrogel. Nature 399(6738):766–769. https://doi.org/10.1038/21619

    Article  CAS  Google Scholar 

  30. Lv Z, Huo Y, Sun L, Chen S, Liu Z, He C, Bi X, Fan X, You Z (2018) A biodegradable functional water-responsive shape memory polymer for biomedical applications. J Mater Chem B. 7. https://doi.org/10.1039/C8TB02462F

  31. Wischke C, Schossig M, Lendlein A (2014) Shape-memory effect of micro-/nanoparticles from thermoplastic multiblock copolymers. Small 10(1):83–87

    Article  CAS  Google Scholar 

  32. Yilmaz F (2017) Aspects of polyurethanes. 2017 Sep 27

  33. Zhang B, Korolj A, Lai BFL et al (2018) Advances in organ-on-a-chip engineering. Nat Rev Mater 3:257–278. https://doi.org/10.1038/s41578-018-0034-7

    Article  Google Scholar 

  34. Rickert D, Moses MA, Lendlein A, Kelch S, Franke RP (2003) The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tissue. Clin Hemorheol Microcirc 28(3):175–181

    CAS  Google Scholar 

  35. Neuss-Stein S, Blomenkamp I, Stainforth R, Boltersdorf D, Jansen M, Butz N, Perez-Bouza A, Knuchel R (2009) The use of a shape-memory poly(ε-caprolactone)dimethacrylate network as a tissue engineering scaffold. Biomaterials 30:1697–1705. https://doi.org/10.1016/j.biomaterials.2008.12.027

    Article  CAS  Google Scholar 

  36. Wang Q (ed) (2017) Smart materials for tissue engineering: applications. Royal Society of Chemistry; 2017

  37. Bao M, Lou X, Zhou Q, Dong W, Yuan H, Zhang Y (2014) Electrospun biomimetic fibrous scaffold from shape memory polymer of PDLLA-co-TMC for bone tissue engineering. ACS applied materials & interfaces. 6. https://doi.org/10.1021/am405101k

  38. Sonawane VC, More MP, Pandey AP, Patil PO, Deshmukh PK (2017) Fabrication and characterization of shape memory polymers based bioabsorbable biomedical drug eluting stent. Artif Cells Nanomed Biotechnol 45(8):1740–1750

    Article  CAS  Google Scholar 

  39. Tamai H, Igaki K, Tsuji T, Kyo E, Kosuga K, Kawashima A, Matsui S, Komori H, Motohara S, Uehata H, Takeuchi E (1999) A biodegradable poly-l-lactic acid coronary stent in the porcine coronary artery. J Interv Cardiol 12:443–450. https://doi.org/10.1111/j.1540-8183.1999.tb00673.x

    Article  Google Scholar 

  40. Baer GM, Small W, Wilson TS, Benett WJ, Matthews DL, Hartman J, Maitland DJ (2007) Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent. Biomed Eng Online 27(6):43. https://doi.org/10.1186/1475-925X-6-43.PMID:18042294;PMCID:PMC2211751

    Article  Google Scholar 

  41. Tibbits S (2014) 4D printing: multi-material shape change. Archit Design 84:116–121. https://doi.org/10.1002/ad.1710

    Article  Google Scholar 

  42. Li Y, Zhang FH, Liu Y, Leng JinSong (2020) 4D printed shape memory polymers and their structures for biomedical applications. Sci China Technol Sci. https://doi.org/10.1007/s11431-019-1494-0

    Article  Google Scholar 

  43. Maroni A, Melocchi A, Zema L, Foppoli A, Gazzaniga A (2020) Retentive drug delivery systems based on shape memory materials. J Appl Polym Sci 137:48798. https://doi.org/10.1002/app.48798

    Article  CAS  Google Scholar 

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Correspondence to Sayan Basak.

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Basak, S. Redesigning the modern applied medical sciences and engineering with shape memory polymers. Adv Compos Hybrid Mater 4, 223–234 (2021). https://doi.org/10.1007/s42114-021-00216-1

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