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Reversible photo-controlled release of bovine serum albumin by azobenzene-containing cellulose nanofibrils-based hydrogel

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Abstract

Development of biomass-based and some other sustainable biomedical materials is a key subject and effective approach to biomass high-value utilization. In this work, we used cellulose resources to develop a photoresponse hydrogel (PR-gel) by integrating 4arm-PEG and azobenzene into cellulose nanofibrils (CNFs). This novel PR-gel exhibited good mechanical strength (storage modulus over 103 Pa), structure stability, reversible recoverability between sustained step strain of 1% and 1000%, and excellent biocompatibility. Under UV irradiation (λ = 365 nm, 10 mW/cm2, 10 min), the azobenzene cross-linker in PR-gel as photoswitch can cause the trans-cis isomerism and a softening effect of the hydrogel, thus realized the photo-controlled release of bovine serum albumin (BSA) (5-fold higher release rate under UV light irradiation). This work provided a new approach to design cellulose-based photoresponsive hydrogels. It is also can expand the application of cellulose-based hydrogels and some other sustainable materials in the biomedical field.

Cellulose nanofibrils-4arm-polyethylene glycol-azobenzene (PR-gel) exhibited good mechanical strength, reversible recoverability, excellent biocompatibility, and reversible photoresponse for protein release.

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Funding

This work was financially supported by the Young Elite Scientists Sponsorship Program by Tianjin (TJSQNTJ-2017-19) and Natural Science Foundation of Tianjin (17JCQNJC05200).

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Authors and Affiliations

  1. Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Lin Dai, Jinshun Lu & Chuanling Si

  2. State Key Laboratory of Biobased Material and Green Papermaking, Key Lab of Paper Science and Technology of Ministry of Education, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, Shandong, People’s Republic of China

    Lin Dai, Fangong Kong, Kefeng Liu & Chuanling Si

  3. College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, People’s Republic of China

    Huige Wei

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  1. Lin Dai
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  2. Jinshun Lu
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Dai, L., Lu, J., Kong, F. et al. Reversible photo-controlled release of bovine serum albumin by azobenzene-containing cellulose nanofibrils-based hydrogel. Adv Compos Hybrid Mater 2, 462–470 (2019). https://doi.org/10.1007/s42114-019-00112-9

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  • DOI: https://doi.org/10.1007/s42114-019-00112-9

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