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Localised Langerhans cell histiocytosis of the hypothalamic-pituitary region: case report and literature review

  • Danijela Radojkovic
  • Milica Pesic
  • Dragan Dimic
  • Tatjana Radjenovic Petkovic
  • Sasa Radenkovic
  • Milena Velojic-Golubovic
  • Vesna Novak
  • Ivan Ilic
  • Milan Radojkovic
Case Report



Langerhans cell histiocytosis (LCH) localised in the hypothalamic-pituitary region (HPR) is very rare, especially in adults. Diabetes insipidus (DI) is considered to be a hallmark of HPR LCH, while anterior pituitary abnormalities are usually seen as consequences of surgery, radiotherapy or chemotherapy.

Case description

We present a patient with localised HPR LCH with dominant anterior pituitary dysfunction and tumour mass effects but without DI. Seven years after surgery and local radiotherapy, she is stable. Control MRI shows no residual tumour growth and thorough physical examination is still without any signs of disease spread.


Anterior pituitary deficiency can appear without DI and not only as a consequence of LCH treatment. All patients with LCH should be screened for this endocrine abnormality so that appropriate substitution therapy may be provided.


Langerhans cell histiocytosis Hypothalamic-pituitary region Anterior pituitary deficiency 


Compliance with ethical standards

Procedures, data collection and presentation were approved by the hospital ethics committee (decision no.: 37232/1). Written informed consent was obtained from the patient to participate and for publication of this case report and any accompanying data.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  • Danijela Radojkovic
    • 1
    • 2
  • Milica Pesic
    • 1
    • 2
  • Dragan Dimic
    • 1
    • 2
  • Tatjana Radjenovic Petkovic
    • 3
  • Sasa Radenkovic
    • 1
    • 2
  • Milena Velojic-Golubovic
    • 1
    • 2
  • Vesna Novak
    • 1
    • 4
  • Ivan Ilic
    • 1
    • 5
  • Milan Radojkovic
    • 1
    • 6
  1. 1.Medical FacultyUniversity of NisNisSerbia
  2. 2.Clinic of Endocrinology, Diabetes and Metabolic DisordersClinical Centre NisNisSerbia
  3. 3.Biochemistry InstituteClinical Centre NisNisSerbia
  4. 4.Neurosurgery ClinicClinical Centre NisNisSerbia
  5. 5.Pathology InstituteClinical Centre NisNisSerbia
  6. 6.Surgery ClinicClinical Centre NisNisSerbia

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