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European Geriatric Medicine

, Volume 9, Issue 3, pp 365–370 | Cite as

Lymphocyte-to-white blood cells ratio in older patients experiencing a first acute heart failure hospitalization

  • Francesc Formiga
  • David Chivite
  • Marta Salvatori
  • Rafael Moreno-Gonzalez
  • Albert Ariza
  • Xavier Corbella
Research Paper
  • 15 Downloads

Abstract

Purpose

Low lymphocyte counts are related to poor health results in heart failure (HF) patients. We assess whether a low lymphocyte-to-white blood cells ratio (LWR) is related to 1-year mortality in older patients experiencing a first hospitalization for acute HF.

Methods

We evaluated 859 patients > 75 years of age admitted within a 33-month period because of a first episode of acute HF. Patients were divided into four groups according to LWR quartiles.

Results

Patients’ mean age was 83.5 ± 5.5 years and their median LWR was 16.7%. After 1 year of follow-up 270 patients (31.43%) died. Mean LWR values were significatively lower in the group of patients who died (15.1 vs. 17.4%; p = 0.001). Mortality rates were significantly higher in the lower LWR quartile either at 1 month, 3 months, and 1 year after the index acute HF episode. The univariate logistic regression analysis identified the LWR (either as quartiles or continuous variable) to be independently associated with higher risk of 1-year post-discharge mortality. Multivariate analysis confirmed this association (HR for LWR as a quartiles variable 1.525; 95% CI 1.161–2.003 and for LWR as a continuous variable 1.145; 95% CI 1.069–1854) besides older age, a higher comorbidity and higher admission potassium.

Conclusions

As is the case in other HF scenarios, a simple routine admission laboratory test such as lymphocyte count can independently predict 1-year mortality for older patients hospitalized for first time due to acute HF.

Keywords

Heart failure Lymphocyte Hospitalization Older Mortality 

Notes

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study conformed to the principles outlined in the Declaration of Helsinki and the ethics committee of the Bellvitge Universitari Hospital approved the overall protocol [PR2016/16].

Informed consent

For this type of study formal consent is not required.

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Copyright information

© European Geriatric Medicine Society 2018

Authors and Affiliations

  • Francesc Formiga
    • 1
  • David Chivite
    • 1
  • Marta Salvatori
    • 2
  • Rafael Moreno-Gonzalez
    • 1
  • Albert Ariza
    • 3
  • Xavier Corbella
    • 1
    • 4
  1. 1.Geriatric Unit, Internal Medicine DepartmentUniversitary Bellvitge Hospital-IDIBELL, Hospital Universitari de BellvitgeBarcelonaSpain
  2. 2.Scuola di Specializzazione in Medicina InternaUniversità degli Studi di MilanoMilanItaly
  3. 3.Cardiology ServiceUniversitary Bellvitge Hospital-IDIBELLBarcelonaSpain
  4. 4.Hestia Chair in Integrated Health and Social Care, Faculty of Medicine and Health SciencesUniversitat Internacional de CatalunyaBarcelonaSpain

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