Zusammenfassung
Neben seiner Funktion als Elektrolyt spielt Magnesium eine entscheidende Rolle im Stoffwechsel. Mehr als 700 Enzymsysteme benötigen Magnesium als Kofaktor. Von zentraler Bedeutung ist das Mineral für den Energiestoffwechsel. Zahlreiche Hormone und Neurotransmitter sowie alle Organe und Gewebe sind zum richtigen Funktionieren auf Magnesium angewiesen. Ein Mangel kann sich folglich in ganz unterschiedlichen Formen manifestieren, was seine Erkennung erschweren kann. Dutzende von Symptomen werden mit einem Magnesiummangel in Verbindung gebracht. Erhebungen lassen vermuten, dass Magnesiummangel in der Bevölkerung weiter verbreitet ist als bislang angenommen. Viele Ursachen können dazu beitragen. Zahlreiche Studien zeigen, dass Magnesium bei der Therapie und Prävention vieler Erkrankungen erfolgreich eingesetzt werden kann. Für einen breiteren Einsatz in der Medizin sprechen die hohe Verträglichkeit, das breite therapeutische Spektrum, die einfache Anwendung, das weitgehende Fehlen von Interaktionen mit Medikamenten, die kurze Halbwertszeit und nicht zuletzt der günstige Preis.
Résumé
En plus de sa fonction d’électrolyte, le magnésium joue un rôle déterminant dans le métabolisme. Plus de 700 enzymes dépendent du magnésium qui leur sert de cofacteur pour fonctionner. Le magnésium est d’une importance primordiale pour le métabolisme lié au système énergétique. Un grand nombre d’hormones et de neurotransmetteurs ainsi que tous les organes et tissus ne fonctionnent qu’en sa présence. Une carence peut se manifester de différentes manières, ce qui rend sa détection difficile dans la plupart des cas. Des douzaines de symptômes peuvent en être à l’origine. Des études basées sur des données collectées par questionnaires suggèrent qu’une carence en magnésium est bien plus répandue que communément admis. Les causes en sont nombreuses. Une multitude d’études démontre l’efficacité thérapeutique et préventive du magnésium dans de nombreuses maladies. Son utilisation plus répandue en médecine s’impose vu sa grande tolérance, son vaste spectre thérapeutique, son utilisation simple, l’absence pratiquement absolue d’interactions médicamenteuses, sa demi-vie courte et notamment, son prix abordable.
Literatur
Rosanoff A (2009) The essential nutrient magnesium—key to Mitochondrial ATP production and much more. https://www.prohealth.com/library/the-essential-nutrient-magnesium-key-to-mitochondrial-atp-production-and-much-more-26273 (Erstellt: 8. Juni 2009)
Hartwig A (2001) Role of magnesium in genomic stability. Mutat Res 475(1–2):113–121
Arigony AL, de Oliveira IM, Machado M et al (2013) The influence of micronutrients in cell culture: a reflection on viability and genomic stability. Biomed Res Int. https://doi.org/10.1155/2013/597282
Rosanoff A, Weaver CM, Rude RK (2012) Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev 70(3):153–164
Seelig MS (1964) The requirement of magnesium by the normal adult. Am J Clin Nutr 14(6):342–390
Seelig MS (1981) Magnesium requirements in human nutrition. Magnes Bull 3(Suppl 1a):26–47
Graham L, Caesar J, Burger A (1960) Gastointestinal absorption and excretion of Mg 28 in man. Metabolism 9:646–659
Glei M et al (1995) Magnesium content of foodstuffs and beverages and magnesium intake of adults in Germany. Magnes Bull 17:22–28
Cashman KD, Flynn A (1999) Optimal nutrition: calcium, magnesium and phosphorus. Proc Nutr Soc 58(2):477–487
Ismail Y, Ismail AA, Ismail AA (2010) The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for “normal” results. Clin Chem Lab Med 48(3):323–327
Mircetić RN et al (2001) Magnesium concentration in plasma, leukocytes and urine of children with intermittent asthma. Clin Chim Acta 312(1–2):197–203
Mauskop A et al (1993) Deficiency in serum ionized magnesium but not total magnesium in patients with migraines. Possible role of ICa2+/IMg2+ ratio. Headache 33(3):135–138
Altura BM, Altura BT (1996) Role of magnesium in patho-physiological processes and the clinical utility of magnesium ion selective electrodes. Scand J Clin Lab Invest 56(Suppl. 224):211–234. https://doi.org/10.3109/00365519609088642
Chazov EI et al (1974) Taurine and electrical activity of the heart. Circ Res 35(Suppl. 3):11–21
Bolland MJ et al (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336(7638):262–266
Bolland MJ et al (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta analysis. BMJ 341:c3691
Bolland MJ et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Woman’s Health Initiative Limited Access Dataset and Meta-Analysis. BMJ 342:d2040
Bolland MJ et al (2013) Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf 4(5):199–210
Nicoll R, Howard JM, Henein MY (2015) A review of the effect of diet on cardiovascular calcification. Int J Mol Sci 16(4):8861–8883
Hruby A, O’Donnell CJ, Jacques PF et al (2014) Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. Jacc Cardiovasc Imaging 7(1):59–69
Maier JA, Malpuech-Brugere C, Zimowska W et al (2004) Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta 1689(1):13–21
Labeeuw M et al (1987) Role of magnesium in the physiopathology and treatment of calcium renal lithiasis. Presse Med 16(1):25–27
Massey L (2005) Magnesium therapy for nephrolithiasis. Magnes Res 18(2):123–126
Liao F, Folsom AR, Brancati FL (1998) Is low magnesium concentration a risk factor for coronary heart disease? The atherosclerosis risk in communities (ARIC) study. Am Heart J 136(3):480–490
Ford ES (1999) Serum magnesium and ischaemic heart disease: findings from a national sample of US adults. Int J Epidemiol 28(4):645–651
Del Gobbo LC, Imamura F, Wu JH et al (2013) Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 98(1):160–173
Guasch-Ferre M, Bullo M, Estruch R et al (2014) Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk. J Nutr 144(1):55–60
Yamori Y, Sagara M, Mizushima S et al (2015) An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations. Hypertens Res 38(3):219–225
Kolte D, Vijayaraghavan K, Khera S et al (2014) Role of magnesium in cardiovascular diseases. Cardiol Rev 22(4):182–192
Kisters K et al (1999) Hypomagnesaemia, borderline hypertension and hyperlipidaemia. Magnes Bull 21:31–34
Resnick LM et al (2000) Factors affecting blood pressure responses to diet: the Vanguard study. Am J Hypertens 13(9):956–965
Rosanoff A, Plesset MR (2013) Oral magnesium supplements decrease high blood pressure (SBP > 155 mm Hg) in hypertensive subjects on anti-hypertensive medications: a targeted meta-analysis. Magnes Res 26(3):93–99
Singh RB et al (1991) Does dietary magnesium modulate blood lipids? Biol Trace Elem Res 30(1):59–64
Corica F et al (1994) Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Magnes Res 7(1):43–47
Durlach J (1996) Commentary on recent epidemiological and clinical advances. Magnes Res 9(2):139–141
King DE et al (2006) Magnesium supplement intake and C‑reactive protein levels in adults. Nutr Res 26(5):193–196
Shechter M et al (2001) Beneficial antithrombotic effects of the association of pharmacological oral magnesium therapy with aspirin in coronary heart disease patients. Magnes Res 13(4):275–284
Parikka HJ, Toivonen LK (1999) Acute effects of intravenous magnesium on ventricular refractoriness and monophasic action potential duration in humans. Scand Cardiovasc J 33(5):300–305
Thiele R et al (2000) Effect of intravenous magnesium on ventricular tachyarrhythmias associated with acute myocardial infarction. Magnes Res 13(2):111–122
Ceremuzyński L et al (2000) Hypermagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. J Intern Med 247(1):78–86
Dyckner T, Wester PO (1984) Magnesium deficiency in congestive heart failure. Acta Pharmacol Toxicol (Copenh) 54(Suppl.s1):119–123
England MR et al (1992) Magnesium administration and dysrhythmias after cardiac surgery. JAMA 268(17):2395–2402
Caspi J et al (1995) Effects of magnesium on myocardial function after coronary artery bypass grafting. Ann Thorac Surg 59(4):942–947
Toraman F et al (2001) Magnesium infusion dramatically decreases the incidence of atrial fibrillation after coronary artery bypass grafting. Ann Thorac Surg 72(4):1256–1262
Teo KK et al (1991) Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomized trials. BMJ 303(6816):1499–1503
Teo KK, Yusuf S (1993) Role of magnesium in reducing mortality in acute myocardial infarction. A review of the evidence. Drugs 46(3):347–359
Woods KL et al (1992) Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 339(8809):1553–1558
Woods KL, Fletcher S (1994) Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 343(8901):816–819
ISIS-4 Collaboration Group (1995) ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate and intravenous magnesium sulphate in 58’050 patients with suspected acute myocardial infarction. Lancet 345(8951):669–682
Seelig MS (1994) Cardiovascular reactions to stress intensified by magnesium deficit, in Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications: a review. J Am Coll Nutr 13(5):429–446
Chiuve SE, Korngold EC, Januzzi JL Jr. et al (2011) Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr 93(2):253–260
Seelig MS (1982) Prenatal and neonatal mineral deficiencies: magnesium, zinc and chromium. In: Lifshitz F (Hrsg) Clinical disorders in Pedriatic nutrition. Marcel Dekker, N.Y., S 167–196
Seelig MS (1991) Magnesium in pregnancy: special needs for the adolescent mother. J Am Coll Nutr 10:566
Caddel JL (2001) Magnesium deficiency promotes muscle weakness, contribution to the risk of sudden infant death (SIDS) in infants sleeping prone. Magnes Res 14(1–2):39–50
Abraham GE (1982) The calcium controversy. J Appl Nutr 34(2). www.mgwater.com
Sojka JE, Weaver CM (1995) Magnesium supplementation and osteoporosis. Nutr Rev 53(3):71–74
Abraham GE, Grewal HA (1990) A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 35(5):503–507
Seelig MS (1990) Increased magnesium need with use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res 3(3):197–215
Orchard TS, Larson JC, Alghothani N et al (2014) Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr 99(4):926–933
Humphries S et al (1999) Low dietary magnesium is associated with insulin resistance in a sample of young, non-diabetic Black Americans. Am J Hypertens 12(8):747–756
Alzaid AA et al (1995) Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. J Clin Endocrinol Metab 80(4):1376–1381
Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G et al (2004) Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 30(3):253–258
Simental-Mendia LE, Sahebkar A, Rodriguez-Moran M et al (2016) A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res 111:272–282
de Lourdes Lima M et al (1998) The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 21(5):682–686
Engelen W et al (2000) Are low magnesium levels in type 1 diabetes associated with electromyographical signs of polyneuropathy? Magnes Res 13(3):197–203
Ma E et al (2010) High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men. J Nutr 140(4):779–785
Wark PA, Lau R, Norat T et al (2012) Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis. Am J Clin Nutr 96(3):622–631
Dibaba D, Xun P, Yokota K et al (2015) Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study. Br J Cancer 113(11):1615–1621
Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A et al (2005) Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 92(11):2076–2083
Ben Q, Xu M, Ning X et al (2011) Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer 47(13):1928–1937
Chari ST, Leibson CL, Rabe KG et al (2008) Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology 134(1):95–101
Song S, Wang B, Zhang X et al (2015) Long-term diabetes mellitus is associated with an increased risk of pancreatic cancer: a Meta-analysis. PLoS ONE 10(7):e134321
Batabyal P, Vander Hoorn S, Christophi C et al (2014) Association of diabetes mellitus and pancreatic adenocarcinoma: a meta-analysis of 88 studies. Ann Surg Oncol 21(7):2453–2462
Stolzenberg-Solomon RZ, Graubard BI, Chari S et al (2005) Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA 294(22):2872–2878
Wolpin BM, Bao Y, Qian ZR et al (2013) Hyperglycemia, insulin resistance, impaired pancreatic beta-cell function, and risk of pancreatic cancer. J Natl Cancer Inst 105(14):1027–1035
Evans JM, Donnelly LA, Emslie-Smith AM et al (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330(7503):1304–1305
Lee MS, Hsu CC, Wahlqvist ML et al (2011) Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 11:20
Wang LW, Li ZS, Zou DW et al (2008) Metformin induces apoptosis of pancreatic cancer cells. World J Gastroenterol 14(47):7192–7198
Sherwood RA et al (1986) Magnesium and the premenstrual syndrome. Ann Clin Biochem 23(6):667–670
Posaci C et al (1994) Plasma copper, zinc and magnesium levels in patients with premenstrual tension syndrome. Acta Obstet Gynecol Scand 73(6):452–455
Muneyvirci-Delale O et al (1998) Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women. Fertil Steril 69(5):958–962
Werbach M (1995) Premenstrual syndrome: magnesium. Townsend Lett Dr 13:26
Facchinetti F et al (1991) Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol Clin North Am 78(2):177–181
Benassi L et al (1992) Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea. Clin Exp Obstet Gynecol 19(3):176–179
Fontana-Klaiber H, Hogg B (1990) Therapeutische Wirkung von Magnesium bei Dysmenorroe. Schweiz Rundsch Med Prax 79(16):491–494
Seifert B et al (1989) Magnesium – a new therapeutic alternative in primary dysmenorrhea. Zentralbl Gynakol 111(11):755–760
Goldberg B (1998) Alternative medicine guide: women’s health series 1. Future Medicine Publishing, Tiburon
Edorh AP et al (2003) Magnesium content in seminal fluid as an indicator of chronic prostatitis. Cell Mol Biol 49:419–423
Seelig MS (1994) Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications: a review. J Am Coll Nutr 13(5):429–446. www.mgwater.com
Conradt A, Weidinger AH (1982) The central position of magnesium in the management of fetal hypotrophy—a contribution to the pathomechanism of utero-placental insufficiency, prematurity and poor intrauterine fetal growth as well as pre-eclampsia. Magnes Bull 4:103–124
Handwerker SM et al (1993) Ionized serum magnesium levels in umbilical cord blood of normal pregnant women at delivery: relationship to calcium, demographics and birthweight. Am J Perinatol 10(5):392–397
Handwerker SM, Altura BT, Altura BM (1996) Serum ionized magnesium and other electrolytes in the antenatal period of human pregnancy. J Am Coll Nutr 15(1):36–43
Almonte RA et al (1999) Gestational magnesium deficiency is deleterious to fetal outcome. Biol Neonate 76(1):26–32
Peikert A, Wilimzig C, Köhne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalagia 16(4):257–263
Chiu HY, Yeh TH, Huang YC et al (2016) Effects of intravenous and oral magnesium on reducing migraine: a Meta-analysis of randomized controlled trials. Pain Physician 19(1):E97–E112
Mauskop A, Varughese J (2012) Why all migraine patients should be treated with magnesium. J Neural Transm (vienna) 119(5):575–579
Talebi M, Savadi-Oskouei D, Farhoudi M et al (2011) Relation between serum magnesium level and migraine attacks. Neurosciences (Riyadh) 16(4):320–323
Charles AC, Baca SM (2013) Cortical spreading depression and migraine. Nat Rev Neurol 9(11):637–644
Sun-Edelstein C, Mauskop A (2009) Role of magnesium in the pathogenesis and treatment of migraine. Expert Rev Neurother 9(3):369–379
Mauskop A et al (1995) Intravenous magnesium sulfate relieves cluster headache in patients with low serum ionized magnesium levels. Headache 35(10):597–600
Werbach MR (1995) Nutritional influences on aggressive behavior. J Orthomol Med 7(1):45–51
Cox RH, Shealy CN et al (1996) Significant magnesium deficiency in depression. J Neur Orth Med Surg 17:7–9
Seelig MS (1998) Review and hypothesis: might patients with the chronic fatigue syndrome have latent tetany of magnesium deficiency. J Chronic Fatigue Syndr 4(2):77–108
Cox IM et al (1991) Red blood cell magnesium and chronic fatigue syndrome. Lancet 337(8744):757–760
Vink R, Nechifor M (2011) Magnesium in the central nervous system. University of Adelaide Press, Adelaide
Gröber U, Kisters K (2017) Arzneimittel als Mikronährstoffräuber, 2. Aufl. Wissenschaftliche Verlagsgesellschaft, Stuttgart
Andersen G (2011) Lebensmitteltabelle für die Praxis, 5. Aufl. Der kleine Souci/Fachmann/Kraut. Wissenschaftliche Verlagsgesellschaft, Stuttgart
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Stegmann, R. Magnesium – das unterschätzte Mineral. J. Gynäkol. Endokrinol. CH 22, 71–82 (2019). https://doi.org/10.1007/s41975-019-0092-2
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DOI: https://doi.org/10.1007/s41975-019-0092-2