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Hydroxyapatite incorporation into MCM-41 and study of ibuprofen drug release

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Abstract

In this study, the mesoporous silica/hydroxyapatite (MCM/HA) was successfully synthesized by a simple one-step method as a controlled drug delivery system. The characterization of mesoporous materials was carried out by X-ray diffraction (XRD), transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (XRF), N2 adsorption/desorption analysis, and ultraviolet spectroscopy. Furthermore, ibuprofen (IBU) drug storage capacities and release rate were studied at in vitro conditions. The XRD and HRTEM results showed the formation of hydroxyapatite nanocrystals into mesoporous silica channels. The BET results indicated that the formation of hydroxyapatite into meso-channels leads to decrease in MCM-41 surface area and pore volume. In addition, the ibuprofen loading and release results showed that adsorption and release behavior of ibuprofen were extremely depended on the interaction of the MCM-41 surface groups and ibuprofen and carrier structural properties in the presence of hydroxyapatite crystals.

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Acknowledgments

Authors gratefully thank the Nanonafez Company in Semnan University Science and Technology Park, Shahroud Branch Islamic Azad University, and Shahroud University of Medical Science for supporting the research work.

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Authors and Affiliations

  1. Department of Medical Radiation Engineering, Faculty of Engineering, Islamic Azad University, Shahrood, Iran

    Amirhosein Toozandeh Jani & Maryam Sheikh Hossein Pour

  2. Department of Midwifery, School of Nursing and Midwifery, Shahroud University of Medical Science, Shahroud, Iran

    Nahid Bolbol Haghighi

  3. Department of Medicine, University of Medical Science of Islamic Republic of Iran Army, Tehran, Iran

    Mohsen Aminian

  4. Department of Laboratory Sciences, School of Medical Science, Shahrood Branch, Islamic Azad University, Shahrood, Iran

    Sahar Molzemi

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  1. Amirhosein Toozandeh Jani
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  2. Nahid Bolbol Haghighi
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  3. Maryam Sheikh Hossein Pour
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  5. Sahar Molzemi
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Correspondence to Sahar Molzemi.

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Jani, A.T., Haghighi, N.B., Sheikh Hossein Pour, M. et al. Hydroxyapatite incorporation into MCM-41 and study of ibuprofen drug release. J Aust Ceram Soc 56, 653–661 (2020). https://doi.org/10.1007/s41779-019-00384-w

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  • DOI: https://doi.org/10.1007/s41779-019-00384-w

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