The aim of this study was to assess the effectiveness of Nd:YAG photobiomodulation (PBM) verse no power placebo with Nd:YAG in the treatment of patients with Burning mouth syndrome (BMS) in pain/burning, numbness, and altered taste.
Methods and materials
Forty-two patients with BMS were randomly equally assigned to PBM group and placebo group. The parameters of 1064-nm laser irradiation consisted of 100 mW power, 3 J/cm2, 30 s/region, and 10HZ. The placebo group used the same PBM instrument which was switched off. Each patient underwent one laser irradiation session per week for 4 weeks. Clinical assessments of subjective pain/burning, numbness, and altered taste were performed using a visual analogue score (VAS) before each irradiation session and 1 week after last treatment.
All of the patients (21) in PBM group were showed significant decrease of VAS value of pain/burning (2% ~100%, mean 52%). The improvement on VAS value of numbness in PBM group (23% ~100%, mean 61%) was significant. Relief of altered taste was found neither in PBM group nor in placebo group. All patients completed this study and none of them reported adverse effects.
One thousand and sixty-four nanometers PBM was effective for reduction of pain/burning and numbness in patients with BMS.
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The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
burning mouth syndrome
randomized controlled trial
visual analogue scale
- Sbaseline :
neodymium-doped yttrium aluminum garnet
the International Association for the Study of Pain
generalized labeled magnitude scale
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The authors thank Dr Zhenyu Wu, Department of Biostatistics of Fudan University, for assistance in statistical analysis and thank the participating patients.
This work was supported by National Natural Science Foundation of China (No. 81671036).
Ethics approval and consent to participate
The study was approved by Committee of Medical Ethics of Shanghai Ninth People’s Hospital (SH9H-2018-T18-2). Written informed consent was obtained from all patients.
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The authors declare no competing interests.
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Sun, C., Xu, P., Zhang, QQ. et al. Nd:YAG photobiomodulation treatment in burning mouth syndrome: a pilot study. Laser Dent Sci (2021). https://doi.org/10.1007/s41547-021-00116-z
- Burning mouth syndrome