Methodological study on endogenous calcium absorptivity using rats and 41Ca tracing

  • Hui Zhang
  • Liang Dou
  • Xiao-Ming Wang
  • Sheng-Quan Mi
  • Qing-Zhang Zhao
  • Shan Jiang
  • Ming He


Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a 41Ca tracer technique in SD rats was conducted to measure the endogenous fecal calcium and true absorption of calcium. Apparent absorption of calcium was measured as a control to the endogenous calcium labeling experiment. These results show that by using 41Ca labeled endogenous calcium in vivo, researchers could obtain the true calcium absorption data without extrinsic labeling. Therefore, the method was not affected by the chemical structure or type of calcium supplement and might be used in evaluating the absorptivity of marketed calcium supplements.


Endogenous calcium absorptivity 41Ca tracer Accelerator mass spectrometry measurement 



We wish to thank experimentalist Lu Zheng from Beijing Union University for her help with the 41Ca biological tracer.


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Copyright information

© Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Chinese Nuclear Society, Science Press China and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Hui Zhang
    • 1
    • 2
  • Liang Dou
    • 1
  • Xiao-Ming Wang
    • 1
  • Sheng-Quan Mi
    • 3
  • Qing-Zhang Zhao
    • 1
  • Shan Jiang
    • 1
  • Ming He
    • 1
  1. 1.China Institute of Atomic EnergyBeijingChina
  2. 2.Technical Physics Institute of Heilongjiang Academy of SciencesHarbinChina
  3. 3.Department of Biology, College of Applied Arts and SciencesBeijing Union UniversityBeijingChina

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