Late preterm infants have a higher risk of early childhood developmental problems than full-term. They usually present subtle neurodevelopmental disabilities that could appear in middle and long-term time. This paper aims to determine differences in child neurodevelopment, in full-term infants and late preterm infants in Ecuadorian Mestizo newborns, using two assessment scales.
This is an epidemiological, cross-sectional, and observational research, with two patient cohorts, late preterm and full-preterm infants. The sample size was 204 individuals, 102 cases in each cohort. It gathers data from the patient’s medical records and of the patients assessed with the Brunet-Lézine scale and Abbreviated Developmental Scale-3.
Among late premature infants, the incidence of developmental disorders was 16.7% and 17.6% of those born at term (p > 0.05). A statistically significant difference was obtained between the first and third developmental evaluations among late preterm infants (p < 0.05). The multivariate analysis identified male sex as a risk factor for developmental disorders. Vaginal delivery and cephalic presentation behaved as protective factors (p < 0.05).
In late preterm and term newborns, where child development was assessed using the Brunet-Lézine Scale and Abbreviated Developmental Scale-3, 16.7% of late preterm and 17.6% of term newborns were found to have developmental disorders, but no statistically significant difference between them. In the multivariate analysis, the most critical risk factor was male sex. Vaginal delivery and cephalic presentation behaved as protective factors.
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The authors thank Gonzalo Mantilla, MD; Luis Eguiguren, MD; and Hugo Burgos, PhD, who, with their conviction and commitment, keep the Prestigious College of Postgraduates in a very important place. Thanks to the members of the Research Ethics Committee in Human Beings (CEISH) at San Francisco University of Quito and especially Ana María Merchán-Tamariz, Coordinator of CEISH-USFQ. Thanks to Alonso Herrera, MD, Leader of the NICU Service; to Linda Arturo Delgado, MD, Delegate of methodological; and Humberto Navas López, MD, Manager of the Isidro Ayora Gyneco-Obstetric Hospital, by allowing us to carry out this research project. And thanks to Lic. Sandra Miño, for her friendship and collaboration.
Conflict of Interest
The authors declare that they have no conflict of interest.
The Institution Review Board and the Research Ethics Committee on Human Beings (CEISH), of the San Francisco University of Quito (USFQ), approved this research.
An informed consent was obtained from all individual participants included in the study.
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Lalangui-Campoverde, A., González-Andrade, F. Comparison of Development of Full-term and Late Preterm Ecuadorian Mestizo Newborns, Using the Brunet-Lézine Scale and the Abbreviated Developmental Scale-3. Adv Neurodev Disord 5, 35–45 (2021). https://doi.org/10.1007/s41252-020-00172-9
- Child development
- Premature birth
- Newborn infant
- Developmental disabilities