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The effect of multi-frequency whole-body vibration on night-shifted mouse model

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Abstract

The circadian rhythm controls several biological activities; therefore, a disorganized circadian rhythm may cause fatal health problems. The aim of this study was to assess the effects of circadian rhythm disturbances induced by simulated night shift activities on the abdominal adipose tissue, bone microstructures and muscle volume in the tibiae of mice. Moreover, we evaluated the effects of multi-frequency whole-body vibration as a countermeasure against the consequences of circadian rhythm disturbances. Twenty-four 5-week-old C57BL/6J male mice were equally assigned to three groups: the normal group (Nor), night shift group (NS), and night shift with multi-frequency whole-body vibration group (NS + V). The NS and NS + V groups were exposed to circadian rhythm disturbances for 4 weeks with 3-day intervals by changing the day and night cycle based on 7 o’clock. After 4 weeks, morphological changes in the adipose tissue, bone microstructures and muscle volume in the tibiae were evaluated from three-dimensional images using in vivo micro-computed tomography. As a result, the volume of the abdominal adipose tissue was significantly higher in the NS than in the Nor and NS + V groups. Also, the microstructures of the tibia were more enhanced in the NS + V than the NS group. The volume of tibial muscle was increased in all groups, while there were no significant changes in muscle volume. From these results, we can conclude that circadian rhythm disturbances induced by night shift activities may reduce bone condition and increase the accumulation of abdominal adipose tissue and these negative effects may be prevented or improved through applying multi-frequency whole-body vibration.

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Acknowledgements

This work was supported by the Yonsei University Future-leading Research Initiative of 2015 (2017-22-0143).

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Author notes

  1. Hana Lee and Seohyun Kim contributed equally to this work.

Authors and Affiliations

  1. Department of Biomedical Engineering, Yonsei University, Wonju, Gangwon, 26493, Republic of Korea

    Hana Lee, Seohyun Kim, Donghyun Hwang, Donghyun Kim, Young-jin Jung & Han Sung Kim

  2. Cell Biotech Inc., Gimpo, Gyeonggi, 10003, Republic of Korea

    Donghyun Seo

  3. CELLOGIN Inc., Wonju, Gangwon, 26354, Republic of Korea

    Seungkwan Cho

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  1. Hana Lee
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Correspondence to Han Sung Kim.

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Ethical Committee Permission and Animals/the protocols for all procedures were approved by the Yonsei University Animal Care Committee (YWC-130729-1) and twenty-four 5-week-old male C57BL/6 mice (19 ± 1.2 g) were used in this study.

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Lee, H., Kim, S., Hwang, D. et al. The effect of multi-frequency whole-body vibration on night-shifted mouse model. Sleep Biol. Rhythms 16, 387–398 (2018). https://doi.org/10.1007/s41105-018-0169-3

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