The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis

Abstract

Platanus orientalis L. has been used in traditional Persian medicine to treat allergic rhinitis. In this study, the therapeutic effects of P. orientalis L. distillate on allergic rhinitis mouse model were assessed. Furthermore, chemical components of P. orientalis L. were analyzed, using gas chromatography–mass spectrometry. Allergic rhinitis was induced in ninety mice using ovalbumin, and they were divided into six groups (group 1: negative control, experienced no treatment; group 2: positive control, received loratadine; groups 3, 4 and 5: received different amounts of P. orientalis L. distillate, orally and group 6: received intranasal P. orientalis L. distillate). Clinical signs, serum level of interleukin 4 and eosinophil counts of nasal mucosa were determined. α-eudesmol and β-eudesmol were found as the major components of the distillate. Clinical signs improved significantly in the groups that had received P. orientalis L. distillate in comparison with the control group. Also, pathological findings were in favor of decrement in the nasal mucosal eosinophil counts. The serum level of interleukin 4 was not in the detectable ranges in any of the groups. Improving effects of P. orientalis L. distillate were observed in allergic rhinitis mouse models.

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Fig. 1

Abbreviations

AR:

Allergic rhinitis

HPF:

High-power field

OVA:

Ovalbumin

P. orientalis L.:

Platanus orientalis L.

TPM:

Traditional Persian Medicine

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Acknowledgements

This study was supported by Shiraz University of Medical Sciences. We are thankful to Mr. Omid Koohi-Hosseynabadi for his contribution in this study. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

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Authors

Contributions

Soheila Alyasin and Reza Amin designed the study, Behjat Maneshian carried out the experiment and prepared the manuscript, Nader Tanideh was contributed in animal study, Ramin Miri was contributed in plant distillate preparation and constituent analysis, Masoud Hosseynzadeh was contributed in the histological assessments, and Narjes Ebrahimi was contributed in data analysis and manuscript preparation. All authors were involved in manuscript drafting, and have read and approved the manuscript.

Corresponding author

Correspondence to Behjat Maneshian.

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Alyasin, S., Maneshian, B., Tanideh, N. et al. The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis. Iran J Sci Technol Trans Sci 44, 21–26 (2020). https://doi.org/10.1007/s40995-019-00813-2

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Keywords

  • Allergic rhinitis
  • Chemical constituents
  • Mouse model
  • Platanus orientalis L.