Skip to main content

Advertisement

SpringerLink
Log in

The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis

  • Research Paper
  • Published:
Iranian Journal of Science and Technology, Transactions A: Science Aims and scope Submit manuscript

Abstract

Platanus orientalis L. has been used in traditional Persian medicine to treat allergic rhinitis. In this study, the therapeutic effects of P. orientalis L. distillate on allergic rhinitis mouse model were assessed. Furthermore, chemical components of P. orientalis L. were analyzed, using gas chromatography–mass spectrometry. Allergic rhinitis was induced in ninety mice using ovalbumin, and they were divided into six groups (group 1: negative control, experienced no treatment; group 2: positive control, received loratadine; groups 3, 4 and 5: received different amounts of P. orientalis L. distillate, orally and group 6: received intranasal P. orientalis L. distillate). Clinical signs, serum level of interleukin 4 and eosinophil counts of nasal mucosa were determined. α-eudesmol and β-eudesmol were found as the major components of the distillate. Clinical signs improved significantly in the groups that had received P. orientalis L. distillate in comparison with the control group. Also, pathological findings were in favor of decrement in the nasal mucosal eosinophil counts. The serum level of interleukin 4 was not in the detectable ranges in any of the groups. Improving effects of P. orientalis L. distillate were observed in allergic rhinitis mouse models.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

AR:

Allergic rhinitis

HPF:

High-power field

OVA:

Ovalbumin

P. orientalis L.:

Platanus orientalis L.

TPM:

Traditional Persian Medicine

References

  • Abolhassanzadeh Z, Aflaki E, Yousefi G, Mohagheghzadeh A (2016) Medicinal plants for joint pain in Traditional Persian Medicine. Trends Pharm Sci 2:89–100

    Google Scholar 

  • Araújo LU, Grabe-Guimarães A, Mosqueira VCF, Carneiro CM, Silva-Barcellos NM (2010) Profile of wound healing process induced by allantoin. Acta Cir Bras 25:460–461

    Article  Google Scholar 

  • Asakura K, Kanemasa T, Minagawa K, Kagawa K, Yagami T, Nakajima M, Ninomiya M (2000) α-Eudesmol, a P/Q-type Ca2+ channel blocker, inhibits neurogenic vasodilation and extravasation following electrical stimulation of trigeminal ganglion. Brain Res 873:94–101

    Article  Google Scholar 

  • Benninger MS, Ahmad N, Marple BF (2003) The safety of intranasal steroids. Otolaryngol Head Neck Surg 129:739–750

    Article  Google Scholar 

  • Bernstein DI, Bernstein CK, Deng C, Murphy KJ, Bernstein IL, Bernstein JA, Shukla R (2002) Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 88:272–278

    Article  Google Scholar 

  • Campanati A et al (2010) Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial. Dermatol Surg 36:1439–1444

    Article  Google Scholar 

  • Finkelman FD, Morris SC (1999) Development of an assay to measure in vivo cytokine production in the mouse. Int Immunol 11:1811–1818

    Article  Google Scholar 

  • Grzincich G, Capra L, Cammarata MG (2004) Effectiveness of intranasal corticosteroids. Acta Bio Med Atenei Parmensis 75:22–25

    Google Scholar 

  • Haider S, Nazreen S, Alam MM, Hamid H, Alam MS (2012) Anti-inflammatory and anti-nociceptive activities of Platanus orientalis Linn. and its ulcerogenic risk evaluation. J Ethnopharmacol 143:236–240

    Article  Google Scholar 

  • Hatami GAAA, Najafi A, Razavi Sh, Afrasiabi K, Afarid M (2003) Prevalence of symptoms and severity of allergic rhinitis, asthma and ectopic eczema in 13-14 years old students in Booshehr. Iran Sout Med J 2:167–175

    Google Scholar 

  • Hossen MA, Fujii Y, Ogawa M, Takubo M, Tsumuro T, Kamei C (2005) Effect of loratadine on mouse models of atopic dermatitis associated pruritus. Int Immunopharmacol 5:1331–1336

    Article  Google Scholar 

  • Lin L, Zheng C, Zhang L, Da C, Zhao K (2011) 2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis. Am J Otolaryngol 32:318–328

    Article  Google Scholar 

  • Ma Y, Hurst HE, Fernandez-Botran R (1996) Soluble cytokine receptors as carrier proteins: effects of soluble interleukin-4 receptors on the pharmacokinetics of murine interleukin-4. J Pharmacol Exp Ther 279:340–350

    Google Scholar 

  • Mirheidar H (1996) Herbal learnings, usage of herbs in prevention and treatment of diseases, vol 3. Islamic Culture Press Center, Tehran

    Google Scholar 

  • Miri S, Farid R, Akbari H, Amin R (2006) Prevalence of allergic rhinitis and nasal smear eosinophilia in 11-to 15 yr-old children in Shiraz. Pediatr Allergy Immunol 17:519–523

    Article  Google Scholar 

  • Mizuki D, Miura T, Sasaki S, Mizuki M, Madarame H, Nakane A (2001) Interference between host resistance to listeria monocytogenes infection and ovalbumin-induced allergic responses in mice. Infect Immun 69:1883–1888

    Article  Google Scholar 

  • Mosaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S (2012) Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J Ethnopharmacol 141:80–95

    Article  Google Scholar 

  • Nasab FK, Khosravi AR (2014) Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran. J Ethnopharmacol 154:190–197

    Article  Google Scholar 

  • Nishanbaev S, Khidyrova N, Kuliev Z (2004) Dimeric proanthocyanidins from platanus orientalis bark. Chem Nat Compd 40:93

    Article  Google Scholar 

  • Nishanbaev S, Kuliev Z, Khidyrova N, Vdovin A, Abdullaev N, Shakhidoyatov KM, Aripov O (2010) New oligomeric proanthocyanidin glycosides platanoside-A and platanoside-B from Platanus orientalis trunk bark. Chem Nat Compd 46:357–362

    Article  Google Scholar 

  • Nishikubo K et al (2003) A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. Gene Ther 10:2119–2125

    Article  Google Scholar 

  • Okano M (2009) Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis. Clin Exp Immunol 158:164–173

    Article  Google Scholar 

  • Sadat-Hosseini M, Farajpour M, Boroomand N, Solaimani-Sardou F (2017) Ethnopharmacological studies of indigenous medicinal plants in the south of Kerman, Iran. J Ethnopharmacol 199:194–204

    Article  Google Scholar 

  • Sadeghi Z, Kuhestani K, Abdollahi V, Mahmood A (2014) Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. J Ethnopharmacol 153:111–118

    Article  Google Scholar 

  • Seo M-J et al (2011) The regulatory mechanism of β-eudesmol is through the suppression of caspase-1 activation in mast cell–mediated inflammatory response. Immunopharmacol Immunotoxicol 33:178–185

    Article  Google Scholar 

  • Spector SL (1997) Overview of comorbid associations of allergic rhinitis. JAllergy Clin Immunol 99:S773–S780

    Article  Google Scholar 

  • Thai QD et al (2016) Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus acerifolia buds. Phytochemistry 130:170–181

    Article  Google Scholar 

  • Tsuneki H et al (2005) Antiangiogenic activity of β-eudesmol in vitro and in vivo. Eur J Pharmacol 512:105–115

    Article  Google Scholar 

  • Wallace DV et al (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122:S1–S84

    Article  Google Scholar 

  • Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M (2006) Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. Clin Exp Immunol 144:475–484

    Article  Google Scholar 

  • Yoshimura M, Enomoto T, Dake Y, Okuno Y, Ikeda H, Cheng L, Obata A (2007) An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int 56:225–230

    Article  Google Scholar 

Download references

Acknowledgements

This study was supported by Shiraz University of Medical Sciences. We are thankful to Mr. Omid Koohi-Hosseynabadi for his contribution in this study. The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

Author information

Authors and Affiliations

  1. Allergy Research Center, Shiraz University of Medical Sciences, P.O. Box 719335899, Shiraz, Iran

    Soheila Alyasin, Reza Amin & Narjes Ebrahimi

  2. Department of Pediatrics, Division of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Science, Shiraz, Iran

    Soheila Alyasin & Reza Amin

  3. Department of Pediatrics, Shiraz University of Medical Sciences, P.O. Box 719335899, Shiraz, Iran

    Behjat Maneshian

  4. Stem Cells Technology Research Center, Shiraz University of Medical Sciences, P.O. Box 7193635899, Shiraz, Iran

    Nader Tanideh

  5. Medical and Natural Products Chemistry Research Center, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 7134853734, Shiraz, Iran

    Ramin Miri

  6. Department of Pathology, Shiraz University of Medical Sciences, P.O. Box 7193711351, Shiraz, Iran

    Masoud Hosseynzadeh

Authors
  1. Soheila Alyasin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Behjat Maneshian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nader Tanideh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ramin Miri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masoud Hosseynzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Reza Amin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Narjes Ebrahimi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Soheila Alyasin and Reza Amin designed the study, Behjat Maneshian carried out the experiment and prepared the manuscript, Nader Tanideh was contributed in animal study, Ramin Miri was contributed in plant distillate preparation and constituent analysis, Masoud Hosseynzadeh was contributed in the histological assessments, and Narjes Ebrahimi was contributed in data analysis and manuscript preparation. All authors were involved in manuscript drafting, and have read and approved the manuscript.

Corresponding author

Correspondence to Behjat Maneshian.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alyasin, S., Maneshian, B., Tanideh, N. et al. The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis. Iran J Sci Technol Trans Sci 44, 21–26 (2020). https://doi.org/10.1007/s40995-019-00813-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40995-019-00813-2

Keywords

Search

Navigation