Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value

Indian Journal of Gynecologic Oncology volume 19, Article number: 24 (2021) Cite this article

Abstract

Backgrounds

Matrix metalloproteinases (MMP) and fascin-1 play roles in epithelial–mesenchymal transition and tumour invasion.

Aims

This study was performed to investigate the relationships of fascin-1 and MMP-9 expression with prognostic parameters in endometrioid-type endometrial carcinoma (EEC).

Methods

A total of 100 cases of EEC were included in the study. Tissues were stained with antibodies against fascin-1 and MMP-9. The relationships between the immunohistochemical findings and clinicopathological prognostic parameters of EEC were examined.

Results

Tumour diameter was significantly related to lymphovascular invasion, FIGO stage and FIGO grade (p < 0.05). A tumour size > 2 cm was associated with a poor prognosis. The staining score for fascin-1 was ≤ 5 in 81 cases and > 5 in 19 cases (p > 0.05), and that for MMP-9 was ≤ 5 in 39 cases and > 5 in 61 cases (p > 0.05). Neither fascin-1 nor MMP-9 expression was significantly related to any of the clinicopathological parameters examined.

Conclusion

There were no significant relationships of fascin-1 and MMP-9 expression with the clinicopathological parameters of EEC. The results of this study suggested that these molecules do not contribute to the clinical behaviour of EECs. A tumour size > 2 cm is associated with a poor prognosis in EEC patients. To verify these results, more studies are needed with larger patient groups.

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Acknowledgements

This project was realised with the contribution of Inonu University Scientific Research Projects Coordination Unit.

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Affiliations

  1. Department of Pathology, Malatya Training and Research Hospital, Malatya, Turkey

    Fahriye Secil Tecellioglu

  2. Department of Pathology, Faculty of Medicine, Inonu University, Malatya, Turkey

    Nusret Akpolat

  3. Department of Pathology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey

    Nurhan Sahin

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  1. Fahriye Secil Tecellioglu
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  2. Nusret Akpolat
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  3. Nurhan Sahin
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Correspondence to Fahriye Secil Tecellioglu.

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Tecellioglu, F.S., Akpolat, N. & Sahin, N. Mmp-9 and Fascin-1 Expression in Endometrioid-Type Endometrial Carcinoma and Their Prognostic Value. Indian J Gynecol Oncolog 19, 24 (2021). https://doi.org/10.1007/s40944-020-00492-7

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Keywords

  • Endometrial carcinoma
  • Endometrium
  • Fascin-1
  • MMP-9
  • Prognosis