Sertoli–Leydig Cell Tumour with Heterologous Element with Rare Mitotic Figure Associated with Multinodular Goitre: A Rare Case of Sex Cord Stromal Tumour of Ovary with Rare Association

  • Meenakshi Gothwal
  • Hemanta Kumar Pradhan
  • Garima Yadav
  • Pratibha Singh
Case Report
  • 17 Downloads

Abstract

Background

Sertoli–Leydig cell tumours are uncommon sex cord stromal tumours of the ovary that often present diagnostic confusion due to the various morphological and histopathological patterns that may be assumed by the tumour.

Case

A 28-year-old female presented with abnormal uterine bleeding and thyromegaly is found to have right adnexal mass with elevated serum testosterone. The mass was diagnosed as a Sertoli–Leydig cell tumour, intermediate differentiation with heterologous elements and focal anaplasia. She was treated with surgical resection followed by adjuvant chemotherapy.

Conclusion

Definitive diagnosis is made by histopathological study with immunohistochemistry. Prognosis is related to the degree of cellular differentiation and to the presence of heterologous elements with stage of disease at the time of diagnosis.

Keywords

Sertoli leydig cell tumour Sex cord stromal tumour Ovary Prognosis Diagnosis Treatment 

Notes

Compliance with Ethical Standards

Conflict of interest

None of the authors have any conflict of interest.

References

  1. 1.
    World Health Organization: WHO classification of tumours of female reproductive organs, vol. 6. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. International Agency for Research on Cancer. 4th ed. Lyon, France; 2014Google Scholar
  2. 2.
    Mills SE, Greenson JK, Hornick JL. Ovarianepithelialstromal tumors, in Sternberg’s diagnostic surgical pathology, vol. 2. 6th ed. Philadelphia: Wolters Kluwer; 2015. p. 2584–7.Google Scholar
  3. 3.
    Chen L, Tunnell CD, De Petris G. Sertoli–Leydig cell tumor with heterologous element: a case report and a review of the literature. Int J Clin Exp Pathol. 2014;7:1176–81.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29:143.CrossRefPubMedGoogle Scholar
  5. 5.
    Abu-Zaid A, Azzam A, Alghuneim LA, Metawee MT, Amin T, Al-Hussain TO. Poorly differentiated ovarian Sertoli–Leydig cell tumor in a 16-year-old single woman: a case report and literature review. Case Obstet Gynecol. 2013;. doi: 10.1155/2013/858501.Google Scholar
  6. 6.
    Zizi-Sermpetzoglou A, Petrakopoulou N, Tepelenis N, Savvaidou V, Manoloudaki K, Katsoulis M. Pure Sertoli cell tumor. a case report and review of the literature. Eur J Gynaecol Oncol. 2010;31(1):117–9.PubMedGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2017

Authors and Affiliations

  • Meenakshi Gothwal
    • 1
  • Hemanta Kumar Pradhan
    • 1
  • Garima Yadav
    • 1
  • Pratibha Singh
    • 1
  1. 1.Department of Obstetrics and GynaecologyAIIMSJodhpurIndia

Personalised recommendations