Study on the Effect of Chemo-Radiation on the Serum Levels of IGF-I in Patients with Cancer Cervix Stage IIIB
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Insulin-like growth factor type 1 (IGF-1) plays an important role in cancer proliferation and drug resistance. There are no published data on serum IGF-1 levels and the effect of chemo-radiotherapy on IGF-1 levels in advanced cervical cancer.
The study was a prospective observational study conducted at a tertiary cancer center. It included patients diagnosed with stage IIIB cervical cancer. Patients were treated with chemo-radiotherapy. IGF-1 levels were measured at baseline, 1 month and 6 months after completion of treatment.
The study included 32 patients with a median age of 42 years. All patients completed the planned treatment. The mean IGF-1 levels at baseline, 1-month and 6-month post-treatment were 168.40 ng/ml, 197.1 ng/ml and 146.51 ng/ml, respectively. The IGF-1 levels increased with treatment (P = 0.13) and then declined on follow-up (P = 0.003). IGF-1 levels did not correlate with tumor size or response to treatment.
Serum IGF-1 levels in advanced cervical cancer increase with chemo-radiotherapy and decline on follow-up. Further studies are required to understand the implication of this finding.
KeywordsCervical cancer IGF Radiotherapy Chemotherapy
Compliance with Ethical Standards
The study was funded by Gujarat Cancer Research Institute.
Conflict of interest
None of the authors have any conflict of interest.
All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- 4.Serum IGF-1 levels. Available at https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=insulin_like_growth_factor. Accessed 14 May 201.