Vitreous Humor Metastasis in Squamous Cell Carcinoma of Cervix
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The orbit is a frequent site of metastasis particularly from breast, prostrate and lung cancers. But cancer cervix metastasizing to the eye is rare.
A 45-year-old woman with a stage 11B, poorly differentiated squamous cell carcinoma cervix, locally controlled with radiotherapy for the last 2 years, presented at the Gyn-Oncology OPD of Acharya Harihar Regional Cancer Centre, Cuttack, with proptosis, eye pain and diminished vision in the left eye, of 1-month duration. She was referred for ophthalmological checkup and was diagnosed to have a growth in the posterior chamber of eye with deposits in the vitreous humor. Histopathological study of the biopsy from the vitreous growth revealed metastatic poorly differentiated squamous cell carcinoma. She received palliative radiotherapy to left eye (30 GY in 10 fractions), along with chemotherapy (paclitaxel and carboplatin).
This resulted in regression of proptosis, decrease in eye pain and improvement of vision.
Later on 7 months after completion of treatment, patient developed local recurrence and died due to disease complication, but metastasis in vitreous humor had disappeared.
KeywordsCervical cancer Metastasis Vitreous humor Squamous cell carcinoma Orbit
Compliance with Ethical Standards
Conflict of interest
The author declares that there are no financial or nonfinancial conflicts of interest.
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