Vitreous Humor Metastasis in Squamous Cell Carcinoma of Cervix

Case Report



The orbit is a frequent site of metastasis particularly from breast, prostrate and lung cancers. But cancer cervix metastasizing to the eye is rare.


A 45-year-old woman with a stage 11B, poorly differentiated squamous cell carcinoma cervix, locally controlled with radiotherapy for the last 2 years, presented at the Gyn-Oncology OPD of Acharya Harihar Regional Cancer Centre, Cuttack, with proptosis, eye pain and diminished vision in the left eye, of 1-month duration. She was referred for ophthalmological checkup and was diagnosed to have a growth in the posterior chamber of eye with deposits in the vitreous humor. Histopathological study of the biopsy from the vitreous growth revealed metastatic poorly differentiated squamous cell carcinoma. She received palliative radiotherapy to left eye (30 GY in 10 fractions), along with chemotherapy (paclitaxel and carboplatin).


This resulted in regression of proptosis, decrease in eye pain and improvement of vision.


Later on 7 months after completion of treatment, patient developed local recurrence and died due to disease complication, but metastasis in vitreous humor had disappeared.


Cervical cancer Metastasis Vitreous humor Squamous cell carcinoma Orbit 


Compliance with Ethical Standards

Conflict of interest

The author declares that there are no financial or nonfinancial conflicts of interest.


  1. 1.
    Ferlay et al. Blockage of cisplatin in the autophagy sensitizes cervical cancer 2015. Funpec-RP http://www.funpecrp.combr/pdf/gmr6828.
  2. 2.
    Bhandari et al., Agarwal U, Dahiya P, Chauhan A et al. Unusual metastasis from carcinoma cervix–JOGI-
  3. 3.
    Ciccone MA. Toe metastasis: a rare pattern of cervical cancer spread 2014. ScienceDirect
  4. 4.
    Uhrinak AN, Tierney KE, Matsuo K. Intraocular metastasis from primary cervical cancer-A case report and review of literature.—Gyn-Oncology reports-Elsevier.
  5. 5.
    Sheilds JA. Orbital metastasis in keratinizingsquamous cell cervical carcinoma. 1989
  6. 6.
    Bloch RS, Gartner S. The incidence of ocular metastatic carcinoma. Arch. Opthalmol. 1971;85:673 (PubMed).CrossRefGoogle Scholar
  7. 7.
    Inove K, Numaga J, Kaji Y, Toda J, Kato S, Sakurai M. Bilateral choroidal metastasis secondary to uterocervical carcinoma of the squamous cell type. Am J. Opthalmol. 2000;30(5):682–4.Google Scholar
  8. 8.
    Kurosawa A, Sawaguchi S. Iris metastasis from squamous cell carcinoma of the uterine cervix. Arch Opthalmol. 1987;105(5):618.CrossRefGoogle Scholar
  9. 9.
    Shibeeb O, Athanasiov P, Simon S, Gilhotra J. Cervical carcinoma manifesting as progressive bilateral visual loss—Case Report. Opthalmol. Med. 2014;2014:75726 (PMCID:4140100) [Pub Med].Google Scholar
  10. 10.
    Wigel T, Kleineidam M, Schilling A. Choroid metastasis in a patient with adenocarcinoma of the cervix—a case report. Strahlenther Onkol. 1995;171(9):539–42.Google Scholar
  11. 11.
    Uhrinak AN, et al. Gynaecological. Oncol Rep. 2015;12:62–3.Google Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2017

Authors and Affiliations

  1. 1.Acharya Harihar Regional Cancer CentreCuttackIndia

Personalised recommendations