Role of Hysterectomy in the Management of Gestational Trophoblastic Neoplasia: Review Citing Three Interesting Cases

  • K. Chitrathara
  • P. SanamEmail author
  • T. J. Simi Raj
  • Neetha Sreedharan
  • O. M. Shajahan
Review Article



Gestational trophoblastic neoplasia (GTN) is characterized by the persistent elevation of beta HCG. It comprises invasive mole, placental site trophoblastic tumor and choriocarcinoma. Effective chemotherapy regimens have largely replaced hysterectomy as a primary mode of treatment in GTN. Even then not all cases can be cured with chemotherapy alone. However, there are still some indications wherein hysterectomy plays a crucial role.


To discuss and emphasize the role of hysterectomy in certain specific situation on Gestational Trophoblastic Neoplasia.


We are citing three interesting scenarios where hysterectomy played a major role in the management of GTN along with the literature review of some of the recent articles that have been published on this topic.


Gestational trophoblastic neoplasia is very chemosensitive; even then surgical extirpation including hysterectomy still has a vital and crucial role in their management. Correct diagnosis and the right time of intervention are the key factors.


Gestational trophoblastic neoplasia Hysterectomy Beta HCG Chemotherapy 


Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interest.


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Copyright information

© Association of Gynecologic Oncologists of India 2017

Authors and Affiliations

  • K. Chitrathara
    • 1
  • P. Sanam
    • 1
    Email author
  • T. J. Simi Raj
    • 1
  • Neetha Sreedharan
    • 1
  • O. M. Shajahan
    • 1
  1. 1.Department of Surgical and Gynecological Oncology, VPS Lakeshore Global LifecareNettoor, KochiIndia

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