Role of Hysterectomy in the Management of Gestational Trophoblastic Neoplasia: Review Citing Three Interesting Cases
Gestational trophoblastic neoplasia (GTN) is characterized by the persistent elevation of beta HCG. It comprises invasive mole, placental site trophoblastic tumor and choriocarcinoma. Effective chemotherapy regimens have largely replaced hysterectomy as a primary mode of treatment in GTN. Even then not all cases can be cured with chemotherapy alone. However, there are still some indications wherein hysterectomy plays a crucial role.
To discuss and emphasize the role of hysterectomy in certain specific situation on Gestational Trophoblastic Neoplasia.
We are citing three interesting scenarios where hysterectomy played a major role in the management of GTN along with the literature review of some of the recent articles that have been published on this topic.
Gestational trophoblastic neoplasia is very chemosensitive; even then surgical extirpation including hysterectomy still has a vital and crucial role in their management. Correct diagnosis and the right time of intervention are the key factors.
KeywordsGestational trophoblastic neoplasia Hysterectomy Beta HCG Chemotherapy
Compliance with Ethical Standards
Conflict of interest
All authors declare that they have no conflict of interest.
- 6.Lorain JR. Advances in the management of high risk gestational trophoblastic tumours. J Reprod Med. 2002;47:451–9.Google Scholar
- 8.Savelli L, Pollastri P, Mabrouk M, Serrachioli R, Venturoli S. Placental site trophoblastic tumour diagnosed on transvaginal sonography. Ultrasound Obstet Gynecol. 2009;34:234–6.Google Scholar
- 14.Medscape: Gestational Trophoblastic tumor treatment protocols. Author: from Memorial Sloan-Kettering—Elizabeth L Jewell, MD, MHSc; Chief Editor: from Memorial Sloan-Kettering—Yukio Sonoda MD Updated: Nov 18, 2015.Google Scholar
- 20.Nakamura T, Iwase A, Ishida C et al. Case report open access journal of clinical case reports ISSN: 2165-7920. A placental site trophoblastic tumor complicated with arteriovenous malformation: a case report. J Clin Case Rep. 2015;5:9. doi: 10.4172/2165-7920.1000596. Volume 5, Issue 9:1000596. J Clin Case Rep ISSN: 2165-7920 JCCR, an open access journal.