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Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era

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Abstract

Purpose of Review

Mesenchymal stem cells (MSCs) have abilities of self-renewal and multi-lineage differentiation. MSCs can evade immune rejection following allogeneic transplantation setting due to their downregulation of HLA Class II antigen. Therefore, we review the current understanding of using MSCs or MSC-conditioned media as treatment for various diseases.

Recent Findings

(1) MSCs regulate the balance of Th17/Treg cells in autoimmune disease models, which is associated with complex interactions among different pro- or anti-inflammation cytokines. (2) With the nature of MSCs migrating to multiple tissues under various homing signals, we also found MSCs are widely used as cell vehicles for gene or chemokine delivery.

Summary

MSCs or MSC-conditioned media therapies have been explored with advanced techniques. However, it still requires further investigations on (1) how MSCs respond to various microenvironments and (2) how to isolate, purify and expand enough MSCs ex vivo.

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Acknowledgments

Many thanks to Dr. Hang Liu, Dr. Amy Bun Tsoi and Dr. Chong Gao for the assistance with the revisions. Works are supported by the donation from Providence Foundation Limited, Hong Kong.

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Authors and Affiliations

  1. Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, 7/F, Laboratory Building, The University of Hong Kong, Room 755, 21 Sassoon Road, Pokfulam, Hong Kong

    Ruixia Deng, Anna Hing Yee Law & Godfrey Chi-Fung Chan

  2. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong

    Ruixia Deng & Jiangang Shen

  3. Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Room 117, 1/F, New Clinical Building, 102 Pokfulam Road, Hong Kong, Hong Kong

    Godfrey Chi-Fung Chan

Authors
  1. Ruixia Deng
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  2. Anna Hing Yee Law
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  3. Jiangang Shen
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  4. Godfrey Chi-Fung Chan
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Correspondence to Godfrey Chi-Fung Chan.

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Ruixia Deng, Anna Hing Yee Law, Jiangang Shen and Godfrey Chi-Fung Chan declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Genome Editing

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Deng, R., Law, A.H.Y., Shen, J. et al. Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era. Curr Stem Cell Rep 4, 327–337 (2018). https://doi.org/10.1007/s40778-018-0147-3

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  • DOI: https://doi.org/10.1007/s40778-018-0147-3

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