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Current Stem Cell Reports

, Volume 4, Issue 4, pp 273–281 | Cite as

Peripheral Blood Stem Cell Mobilization: a Look Ahead

  • Louis M. PelusEmail author
  • Hal E. Broxmeyer
In Vitro and In Vivo Models in Stem Cell Biology (E Scott, Section Editor)
Part of the following topical collections:
  1. Topical Collection on In Vitro and In Vivo Models in Stem Cell Biology

Abstract

Purpose of Review

Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers is difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remain an area of interest. This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.

Recent Findings

Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress identify strategies to collect more potent competing HSC, and new methods to optimize stem cell collection and engraftment are being evaluated.

Summary

Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.

Keywords

Peripheral blood stem cell mobilization Hematopoietic stem cells Stem cell collection HSC egress High-engrafting stem cells Hypoxic collection 

Notes

Acknowledgements

References in this review from the co-authors were supported by the National Institutes of Health Grants HL096305, AG046246, CA182947, DOD PR140433 (to LMP), and HL056416, HL112669, DK109188 HL139599, DK106846 (to HEB)

Compliance with Ethical Standards

Conflict of Interest

Louis M. Pelus and Hal E. Broxmeyer declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Microbiology & ImmunologyIndiana University School of MedicineIndianapolisUSA

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