Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate
Purpose of Review
Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of hematopoietic stem cell (HSC) homeostasis and hematopoietic differentiation.
Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.
Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.
KeywordsHematopoiesis Long noncoding RNA HSC Cell fate Differentiation
This work was supported by the National Cancer Institute of the NIH under Award P30CA033572. This work was funded in part by the NIH AI125615, the Nesvig Lymphoma Research Fund at the City of Hope and the Research Career Development award (to M.P.B.) by the STOP CANCER Foundation.
Compliance with Ethical Standards
Conflict of Interest
Nathaniel Magilnick and Mark P. Boldin declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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