Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate

Role of Classical Signaling Pathways in Stem Cell Maintenance (A Cardoso and N Carlesso, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Role of Classical Signaling Pathways in Stem Cell Maintenance

Abstract

Purpose of Review

Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of hematopoietic stem cell (HSC) homeostasis and hematopoietic differentiation.

Recent Findings

Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.

Summary

Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.

Keywords

Hematopoiesis Long noncoding RNA HSC Cell fate Differentiation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Nathaniel Magilnick and Mark P. Boldin declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Disclaimer

The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiologyBeckman Research Institute at the City of HopeDuarteUSA

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