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“Sea”-ing Is Believing: In Vivo Imaging of Hematopoietic Stem Cells and Cancer Using Zebrafish

  • In Vitro and In Vivo Models in Stem Cell Biology (E Scott, Section Editor)
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Abstract

Purpose of Review

Communication between cells and their environment regulates their behaviors. Like a naturalist who watches animals to understand them, visualizing cells within their native ecosystems provides clues into how they work. In this review, we discuss recent findings using in vivo imaging in zebrafish to understand the behaviors of hematopoietic stem and progenitor cells (HSPCs) and cancer.

Recent Findings

Recent studies visualizing the birth and migration of HSPCs throughout development and adulthood have revealed the contributions of signals from somites, immune cells, and stromal cells in modulating HSPC fate decisions. New studies in zebrafish cancer have also revealed the earliest initiation of tumorigenesis, the complex interplay of heterogenous tumor cells with each other and their environment, and how these interactions influence tumor migration and metastasis.

Summary

These insights aid our understanding of cell-cell communications that are critical for making advances in regenerative medicine and cancer therapeutics.

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Author notes

  1. Samima Habbsa and Mia McKinstry contributed equally.

Authors and Affiliations

  1. Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Samima Habbsa, Mia McKinstry & Teresa V. Bowman

  2. Department of Developmental & Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Samima Habbsa, Mia McKinstry & Teresa V. Bowman

  3. Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Teresa V. Bowman

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  1. Samima Habbsa
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Samima Habbsa, Mia McKinstry, and Teresa V. Bowman declare that they have no conflict of interest.

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Habbsa, S., McKinstry, M. & Bowman, T.V. “Sea”-ing Is Believing: In Vivo Imaging of Hematopoietic Stem Cells and Cancer Using Zebrafish. Curr Stem Cell Rep 3, 181–191 (2017). https://doi.org/10.1007/s40778-017-0088-2

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