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Updates in Eosinophilic Esophagitis

  • Pediatric Gastroenterology (SA Saeed and E Mezoff, Section Editors)
  • Published:
Current Treatment Options in Pediatrics Aims and scope Submit manuscript

Abstract

Purpose of review

Eosinophilic esophagitis (EoE) is an increasingly common allergic condition managed by a diverse group of practitioners including gastroenterologists, allergists, primary care, and emergency care providers. One of the major gaps in the care of patients with EoE is delay in diagnosis that is in part due to the varied presentation by age and gaps in disease awareness. Prompt recognition and referral to a gastroenterologist for consideration of esophagogastroduodenoscopy (EGD) with biopsies are necessary for diagnosis and subsequent access to directed therapies for patients with EoE.

Recent findings

The recent United States Food and Drug Administration (FDA) approval of dupilumab marks a milestone in the treatment of EoE. It is the first treatment option for EoE to gain FDA approval and joins the list of effective therapies for patients with EoE, including proton pump inhibitors, topical corticosteroids, dietary eliminations, and dilations.

Summary

The prompt recognition, diagnosis, and effective treatment of EoE are challenging, but the progress made over the past three decades has enhanced our ability to manage EoE. Continued refinement of current as well as innovative new diagnostic and therapeutic modalities will further help providers, patients with EoE, and their caregivers.

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Data Availability

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References and Recommended Reading

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Authors and Affiliations

  1. Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, Birmingham, Alabama, 35233-1711, USA

    Diana Montoya-Melo MD, Nicholas CaJacob MD & Sandeep K. Gupta MD

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DM and NC wrote the main manuscript text. All authors reviewed the manuscript.

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Correspondence to Nicholas CaJacob MD.

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Sandeep K. Gupta has received indirect research support from Allakos, Ellodi, and AstraZeneca. Sandeep K. Gupta has received honoraria from Ellodi, BMS, Shire, MedScape, PeerView Institute, and Focus Medical Communications. Sandeep K. Gupta has received royalties from UpToDate.

Diana Montoya-Melo has no relevant non-financial interests to disclose. Nicholas CaJacob has no relevant non-financial interests to disclose.

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Montoya-Melo, D., CaJacob, N. & Gupta, S.K. Updates in Eosinophilic Esophagitis. Curr Treat Options Peds 9, 224–237 (2023). https://doi.org/10.1007/s40746-023-00289-8

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