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A Review of Short Bowel Syndrome Including Current and Emerging Management Strategies

  • Pediatric Gastroenterology (SA Saeed and K Sandberg, Section Editors)
  • Published:
Current Treatment Options in Pediatrics Aims and scope Submit manuscript

Abstract

Purpose of review

Short bowel syndrome occurs as a consequence of congenital or acquired bowel loss that leads to myriad manifestations and a need for specialized nutritional therapy. It is a common cause of intestinal failure. This review seeks to summarize the scope of disease burden, review comorbidities, and emphasize current and evolving treatment strategies.

Recent findings

The implementation of multidisciplinary intestinal rehabilitation programs has improved patient outcomes. Lipid minimization and availability of alternative lipid emulsions, such as Omegaven and SMOFlipid, have been important to reducing intestinal failure–associated liver disease. Teduglutide, an analog of glucagon-like peptide 2, promotes intestinal adaptation and holds a promising future as an emerging treatment option.

Summary

Management is nuanced and complex with considerations related to nutrition, growth, liver health, vascular integrity, bone health, infectious risks, neurodevelopment, and quality of life. New opportunities for collaborative, prospective, multisite research are emerging with the widespread application of electronic medical records and the possibility of integrated multicenter databases. Ongoing research efforts seek to further optimize intestinal adaptation through pharmacologic and non-pharmacologic means.

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References and Recommended Reading

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  1. Center for Intestinal Rehabilitation and Nutrition Support, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH, 43205, USA

    Colleen B. Flahive MD, Monique Goldschmidt MD & Ethan A. Mezoff MD

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Flahive, C.B., Goldschmidt, M. & Mezoff, E.A. A Review of Short Bowel Syndrome Including Current and Emerging Management Strategies. Curr Treat Options Peds 7, 1–16 (2021). https://doi.org/10.1007/s40746-020-00218-z

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