Anaphylaxis to lidocaine and cross-reactivity to articaine and prilocaine with tolerance to bupivacaine

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  1. 1.

    Boren E, Teuber SS, Naguwa SM, Gershwin ME. A critical review of local anesthetic sensitivity. Clin Rev Allergy Immunol. 2007;32:119–28.

    CAS  Article  Google Scholar 

  2. 2.

    Batinac T, Sotošek Tokmadžić V, Peharda V, Brajac I. Adverse reactions and alleged allergy to local anesthetics: analysis of 331 patients. J Dermatol. 2013;40:522–7.

    CAS  Article  Google Scholar 

  3. 3.

    Rosa Duque JS, Chong PC, Lau YL, Ho MH. Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anesthetics. Asian Pac J Allergy Immunol. 2019;37:179–82.

    PubMed  Google Scholar 

  4. 4.

    Prieto A, Herrero T, Rubio M, Tornero P, Baeza ML, Velloso A, et al. Urticaria due to mepivacaine with tolerance to lidocaine and bupivacaine. Allergy. 2005;60:261–2.

    CAS  Article  Google Scholar 

  5. 5.

    Ing Lorenzini K, Gay-Crosier Chabry F, Piguet C, Desmeules J. Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anesthetics. J Allergy Clin Immunol Pract. 2016;4:162–4.

    Article  Google Scholar 

  6. 6.

    Davila-Fernández G, Sánchez-Morillas L, Rojas P, Laguna JJ. Urticaria due to an intradermal test with articaine hydrochloride. J Investig Allergol Clin Immunol. 2012;22:373–4.

    PubMed  Google Scholar 

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Correspondence to Ozge Can Bostan.

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O.C. Bostan, M.E. Cakmak, S.B. Kaya, E. Celebioglu, G. Karakaya and A.F. Kalyoncu declare that they have no competing interests.

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Bostan, O.C., Cakmak, M.E., Kaya, S.B. et al. Anaphylaxis to lidocaine and cross-reactivity to articaine and prilocaine with tolerance to bupivacaine. Allergo J Int (2020).

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  • Local anesthetics
  • Cross-reactivity
  • Drug hypersensitivity
  • Drug allergy
  • Amide group anesthetics