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The effect of polymorphism of uric acid transporters on uric acid transport

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Abstract

The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. One of them is transporters which are responsible for the debouchment of uric acid within blood. The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on. In recent years, a large number of genome-wide association studies have shown that the single nucleotide polymorphisms of uric acid transporters were closely related to serum uric acid level. What’s more, some mutations on these gene locus may also break the balance of serum uric acid. Here, the polymorphisms of uric acid transporters closely related with the serum uric acid balance were reviewed and discussed because of their important significance in clinical therapy for a precision medicine. The mechanism of metabolic diseases with gene variation may provide new strategy for the design and development of innovative drug to treat diseases with uric acid metabolic disturbance.

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Acknowledgements

The authors thank all the members of their laboratories who have contributed much of the work discussed in this review.

Funding

This work was supported by National natural science foundation key project [Grant number 81430096]; National natural science foundation youth science fund project [Grant number 81503154]; National Science Foundation for Post-doctoral Researchers [Grant number 2015M570231]; Program for Changjiang Scholars and Innovative Research Team in University [grant number IRT_14R41]; Key Projects of Tianjin Science and Technology Support Program [Grant number 16YFZCSY00440]; Science and Technology Program of Tianjin [Grant number 15PTCYSY00030] and Tianjin Research Program of Application Foundation and Advanced Technology [Grant number 15JCQNJC14100].

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Authors and Affiliations

  1. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

    Ze Wang, Tao Cui, Fang Zhao, Yinghui Sun, Rui Liu & Changxiao Liu

  2. State Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research New Drug Evaluation Research, Tianjin, 300031, China

    Xiaoyan Ci, Weidang Wu, Xiulin Yi & Changxiao Liu

  3. Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China

    Yazhuo Li, Xiulin Yi & Changxiao Liu

Authors
  1. Ze Wang
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  2. Tao Cui
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  3. Xiaoyan Ci
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  4. Fang Zhao
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  5. Yinghui Sun
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  6. Yazhuo Li
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  7. Rui Liu
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  8. Weidang Wu
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  9. Xiulin Yi
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  10. Changxiao Liu
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Corresponding authors

Correspondence to Weidang Wu or Xiulin Yi.

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Wang, Z., Cui, T., Ci, X. et al. The effect of polymorphism of uric acid transporters on uric acid transport. J Nephrol 32, 177–187 (2019). https://doi.org/10.1007/s40620-018-0546-7

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  • DOI: https://doi.org/10.1007/s40620-018-0546-7

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