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Abdominal aortic calcification and renal resistive index in patients with chronic kidney disease: is there a connection?

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Abstract

Background

We aimed to evaluate the relationship between abdominal aortic calcification (AAC) and renal resistive index (RRI), parameters associated with cardiovascular outcome, in non-dialysis chronic kidney disease (CKD) patients.

Methods

Seventy-seven stable patients mainly in CKD stages 3B and 4 (44 and 28 %), median age 69 years, with a positive history of systemic atherosclerosis were prospectively enrolled. RRI, carotid intima-media thickness (IMT), Kauppila score for AAC (AACs), cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) were assessed. Traditional and non-traditional atherosclerosis risk factors were also evaluated.

Results

Vascular (50 %), diabetic (26 %) and primary glomerular nephropathies (8 %) were the main causes of CKD. AAC was highly prevalent (77 %). In the whole cohort, RRI was directly related to AACs (rs = 0.35, p < 0.001). AACs correctly identified patients with RRI >0.7 in 69 % (56–81 %) of cases, a cut-off of 5 resulting the best combination of sensitivity (65 %) and specificity (68 %). Compared to those with AACs <5, patients with AACs >5 were older, had higher serum cholesterol, C-reactive protein and IMT, lower ABI, but similar CAVI, estimated glomerular filtration rate, serum calcium and phosphate. In the whole cohort, AACs was negatively correlated with ABI (rs = −0.51, p < 0.001) and positively with IMT (rs = 0.27, p = 0.01), supporting a role for Kauppila score in integrating information on both intra- and extrarenal atherosclerosis.

Conclusions

As Kauppila score correlates with RRI in non-dialysis CKD patients, it could be a fast, convenient and relatively inexpensive tool for estimating RRI, and consequently the intrarenal vascular status, but further research is warranted.

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Conflict of interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Nephrology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Cristina Capusa, Simona Stancu, Ligia Petrescu, Iuliana Andreiana & Gabriel Mircescu

  2. “Dr. Carol Davila” Teaching Hospital of Nephrology, Bucharest, Romania

    Gabriel Stefan, Cristina Capusa, Simona Stancu, Ligia Petrescu, Iuliana Andreiana & Gabriel Mircescu

  3. Department of Radiology and Medical Imaging, Delta Hospital, Bucharest, Romania

    Elena Dana Nedelcu

Authors
  1. Gabriel Stefan
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  2. Cristina Capusa
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  3. Simona Stancu
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  4. Ligia Petrescu
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  5. Elena Dana Nedelcu
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  6. Iuliana Andreiana
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  7. Gabriel Mircescu
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Correspondence to Cristina Capusa.

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Stefan, G., Capusa, C., Stancu, S. et al. Abdominal aortic calcification and renal resistive index in patients with chronic kidney disease: is there a connection?. J Nephrol 27, 173–179 (2014). https://doi.org/10.1007/s40620-013-0021-4

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  • DOI: https://doi.org/10.1007/s40620-013-0021-4

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