Table 3 Summary of the results of currents studies on ECG features in acromegaly patients

From: Electrophysiological features in acromegaly: re-thinking the arrhythmic risk?

Arrhythmia classification ECG features Study characteristic and method Reference
Supraventricular Isolated SVPB: 89%
Paired SVPB: 39%
NS-SVT: 46%
p not significant
36 naïve ACRO
24 h-Holter*
[25]
SVPBs (> 50/h): 16.6% 19 naïve pts
24 h-Holter
[76]
AF due to valve disease 2 ACRO, case report [98]
AF due to valve disease Case report [99]
ST + SVPB: 15% 35 active ACRO
24 h-Holter*
[88]
Ventricular NS-VT: 9%
Isolated VPB: 38%
Multiple VPB: 13%
p not significant
59 active ACRO vs 70 CON [53]
Isolated VPB: 71%
Paired VPB: 21%
NS-VT: 11%
p not significant
36 naïve ACRO
24 h-Holter
[24]
Complex VPB at stress ECG: 6%
VPB (10–100/24 h): 19% (p < 0.01)
VPB (100–1000/24 h): 25% (p < 0.01)
VPB (> 1000/24 h): 12.5% (p < 0.01)
Paired VPB: 37.5% (p < 0.01)
Triplets: 6%
VT: 12.5%
32 ACRO vs 50 CON
19 active disease
[20]
“Frequent ventricular extrasystoles”: 38%
S-VT: 3% (1 ACRO)
p not significant
34 ACRO vs 22 CON
10 active ACRO
ECG + 24 h-Holter
[27]
VPB: 18%
p not significant
17 ACRO vs 17 CON
15 active ACRO
ECG + 24 h-Holter
[65]
VPB (> 50/24 h): 33.3% 19 naïve ACRO
24 h-Holter*
[76]
Intermittent monomorphic VT Case report [32]
VT Case report [23]
VT + VPB Case report [100]
VF Case report [31]
Ventricular tachycardia Case report [101]
Other features Sick sinus syndrome Case report [24]
Third grade AV block Case report [32]
Third grade AV block Case report [33]
Sinus pause (1 ACRO) 35pts with active disease [88]
LAFB: 18.75%
First grade AV block: 6.25%
  [20]
RBBB: 5.88% (2 ACRO)
LBBB: 5.88% (2 ACRO)
Sinus pauses: 5.88% (2 ACRO)
  [27]
  1. SVPB supra-ventricular premature beats, VPB ventricular premature beat, SVT supra ventricular tachycardia, VT ventricular tachycardia, NS non-sustained, S sustained ECG electrocardiogram, ACRO acromegalic patient, AF atrial fibrillation, ST sinus tachycardia, CON controls, VF ventricular fibrillation, LAFB left anterior fascicular block, AV atrio-ventricular, RBBB right bundle branch block, LBBB left bundle branch block
  2. *Longitudinal study, not general population control group