Weight loss effect of liraglutide in real-life: the experience of a single Italian obesity center

Abstract

Purpose

Several randomized controlled clinical trials (RCCTs) have shown that the use of Liraglutide (L) in addition to diet and exercise in patients with obesity or overweight (OO), compared to dietary behavioral changes alone, leads to a significantly greater weight loss. This retrospective study aimed at evaluating the effectiveness of L therapy in a real-life setting.

Methods

93 consecutive non-diabetic OO, referring to a single Obesity Center, started L therapy from October 2016 to December 2018: 21/93 OO discontinued the treatment within 90 days for various reasons. 72/93 OO (55 females, 17 males), mean ± SD age 49 ± 12.5 years (18–78) and mean body mass index 39.1 ± 5.8 (28.3–55.3) were included for further analysis. 60/72 OO reached the final dose of 3.0 mg/day.

Results

Mean weight loss was 7.1% in the OO who reached the dose of 3.0 mg; 68.3%, 20.0% and 10.0% of OO lost ≥ 5%, 10% and 15% of body weight, respectively. A linear correlation between early and final weight loss was found. Moreover, we observed a significant reduction of mean systolic and diastolic blood pressure and a significant increase of mean heart rate. The overall incidence of side effects was 18.3% (17/93).

Conclusion

L treatment of OO in a real life setting yielded results comparable to those reported by the major RCCTs. Combining the results of RCCTs with the observations from real life may increase their power and overcome their respective limitations.

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Aknowledgements

We thank Dr. Paolo Piaggi for his support in statistical analysis. We acknowledge Graphpad version 5 was used to create the artwork.

Funding

This research was partially funded by the Italian Ministry of the University, Project code 2017L8Z2EM: Mechanisms of adipose tissue dysfunction in obesity: a target of future weight loss strategies for the prevention of diabetes and cardiovascular diseases.

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Affiliations

Authors

Contributions

FF, PF, GSa, FS contributed to the study design. PF, GSa, GSc, AM, RJ and JV performed outpatient visits and selected patients. Data collection was carried out by FF, PF and SM. FF, GC, FS performed the statistical analysis and drew the figures. FF, PF, GC and FS wrote the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to F. Santini.

Ethics declarations

Conflicts of interest

F.F. has received travel funds from the following companies involved with lipodystrophy, obesity and/or diabetes treatments: Novo Nordisk, Aegerion, Amryt Pharmaceuticals.P.F has received travel funds from the following companies involved with obesity and/or diabetes treatments: Novo Nordisk, Bruno Farmaceutici, LJ Pharma. G.S. has received fees for sponsor seminar and travel funds from the following companies involved with obesity and/or diabetes treatments: Novo Nordisk, Penta. R.J. has received travel funds from the following companies involved with obesity and/or diabetes treatments: Novo Nordisk, Bioitalia, Nestlè, Kalibra. J.V. has received travel funds from the following companies involved with obesity and/or diabetes treatments: Novo Nordisk, Kalibra, GlaxoSmithKline. G.S. has received travel funds from the following company involved with obesity and/or diabetes treatments: Novo Nordisk. A.M. has received travel funds from the following company involved with obesity and/or diabetes treatments: Novo Nordisk. S.M. has received travel funds from the following companies involved with lipodystrophy, obesity and/or diabetes treatments: Novo Nordisk, Aegerion, Amryt Pharmaceuticals.G.C. has received fees for consulting, and/or received travel funds from the following companies that are involved with lipodystrophy, obesity and/or diabetes treatments: AstraZeneca, Aegerion, Novonordisk, Amryt Pharmaceuticals and Rhythm Pharmaceuticals. F.S. has worked as a consultant, participated in studies and/or received travel funds from the following companies that are involved with lipodystrophy, obesity and/or diabetes treatments: AstraZeneca, Aegerion, Amryt Pharmaceuticals, Bruno Farmaceutici, Novo Nordisk.

Ethics approval

All procedures performed in this study were in accordance with the ethical standards of the Local Ethical Committee and with the 1964 Helsinki declaration and its later amendments.

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Patients gave a general consent to the use of anonimysed data for research purpose.

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Ferrari, F., Fierabracci, P., Salvetti, G. et al. Weight loss effect of liraglutide in real-life: the experience of a single Italian obesity center. J Endocrinol Invest (2020). https://doi.org/10.1007/s40618-020-01334-1

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Keywords

  • Obesity
  • Obesity therapy
  • Liraglutide
  • Real life experience
  • Weight loss