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Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls

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Abstract

Purpose

Increased arterial stiffness is an early sign of endothelial dysfunction. Nevertheless, measures of the elastic properties of the aortic root in patients with type 1 diabetes are still lacking. The aim of this study was to compare aortic root stiffness index in type 1 diabetes and healthy controls.

Methods

Ninety-three patients with type 1 diabetes without cardiovascular diseases were recruited and compared to 33 healthy controls. Aortic root elastic properties were estimated by measuring the systolic and diastolic diameters on M-mode acquisition.

Results

None of the subjects showed alterations of either systolic or diastolic echocardiographic parameters. Patients with type 1 diabetes had a very low prevalence of chronic complications and their metabolic control was good. Significantly increased aortic stiffness index was found in type 1 diabetes compared to controls, and the same different pattern was found in men and women. The presence of type 1 diabetes and increased pulse pressure was significantly associated with aortic stiffness index in a multivariate linear analysis.

Conclusion

This study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes.

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Funding

No funds were provided for this study.

Author information

Authors and Affiliations

  1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, Piazzale Stefani, 1, 37126, Verona, Italy

    G. Zoppini, M. Trombetta, M. Dauriz, A. Mantovani, G. Targher, I. Fossà, E. Rinaldi & E. Bonora

  2. Section of Cardiology, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

    C. Bergamini & L. Sabbagh

Authors
  1. G. Zoppini
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  2. C. Bergamini
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  3. M. Trombetta
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  4. L. Sabbagh
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  5. M. Dauriz
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  6. A. Mantovani
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  7. G. Targher
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  8. I. Fossà
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  9. E. Rinaldi
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  10. E. Bonora
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Contributions

CBLS performed the echocardiographic study. GZ wrote the manuscript and analyzed data. GT, MD, MT, EB reviewed/edited the manuscript. AM, IF, ER contributed to the preparation of the data and to the discussion. GZ is the guarantor.

Corresponding author

Correspondence to G. Zoppini.

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Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

The study was approved by the local ethics committee.

Informed consent

Informed consent was obtained from each participant.

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Zoppini, G., Bergamini, C., Trombetta, M. et al. Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls. J Endocrinol Invest 42, 1109–1115 (2019). https://doi.org/10.1007/s40618-019-01032-7

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  • DOI: https://doi.org/10.1007/s40618-019-01032-7

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