20S proteasome in the blood plasma of boys with cryptorchidism
To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism.
Patients—50 boys aged 1–4 years (median = 2.4 years) with unilateral cryptorchidism. The control group—50 healthy, age-matched boys (aged 1–4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging.
The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old.
We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.
KeywordsProteasome Cryptorchidism Boys SPR imaging
Surface plasmon resonance imaging
Zygote-specific proteasome assembly chaperone
No external funding for this manuscript.
Compliance with ethical standards
Conflict of interest
The other authors have indicated they have no potential conflicts of interest to disclose.
The study was approved by the local Ethics Committee. All parents gave their informed, written consent for the inclusion to the study, clinical and biochemical follow-up, and for surgical treatment. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Study was approved by the Ethics Committee of Medical University of Bialystok Poland.
Informed consent was obtained from all individual participants included in the study.
The other authors have indicated they have no financial relationships relevant to this article to disclose.
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