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Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study

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Abstract

Purpose

The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR study.

Methods

PREDATORR was an epidemiological study with a stratified, cross-sectional, cluster random sampling design. Participants were classified into four cardiometabolic phenotypes based on the BMI, the cut-off value being 25 kg/m2, and the presence of MetS (defined according to the Harmonization definition 2009): MUHL, MHO, metabolically healthy lean (MHL) and metabolically unhealthy overweight/obese (MUHO).

Results

Overall, 2681 subjects aged 20–79 years were included in the analysis. The overall age and sex-adjusted prevalence of obesity was 31.90 %, overweight was 34.7 %, abdominal obesity was 73.90 % and MetS was 38.50 %. The age- and sex-adjusted prevalence of MHO phenotype was 31.60 %, while MUHL phenotype prevalence was 3.90 %. MUHL and MHO participants had a cardiometabolic profile, kidney function and CVD risk intermediary between MHL and MUHO. MUHL had higher odds of being associated with CVD risk (OR 5.8; p < 0.001), abdominal obesity, prediabetes, diabetes, hypertriglyceridemia and hypo-HDL cholesterolemia than MHL, while MHO phenotype was associated with hypo-HDL cholesterolemia (OR 3.1; p = 0.002), prediabetes (OR 2.9; p < 0.001) and abdominal obesity.

Conclusions

PREDATORR study showed a high prevalence of obesity/overweight, abdominal obesity and MetS in the adult Romanian population, and their association with kidney function and several cardiometabolic factors.

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Acknowledgments

The authors would like to thank the 101 general practitioners (enrolled the participants and filled in the study questionnaires), CEBIS International (study feasibility, project management and statistical analysis), Prof. Dr. Cristian Băicuș (validation of the statistical analyses), Adriana Rusu and Iudit-Hajnal Filip (XPE Pharma&Science) for writing support.

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Author notes

    Authors and Affiliations

    1. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania

      S. Popa, M. Moţa & E. Moţa

    2. Emergency Clinical Hospital Craiova, Craiova, Romania

      A. Popa

    3. University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania

      C. Serafinceanu, C. Guja, R. Lichiardopol & G. Radulian

    4. University “Ovidius”Constanţa, Constanţa, Romania

      D. Catrinoiu

    5. University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania

      N. Hâncu, C. Bala & G. Roman

    6. University Oradea, Oradea, Romania

      A. Popa

    7. University of Medicine and Pharmacy “Victor Babeș”, Timișoara, Romania

      R. Timar

    8. University of Medicine and Pharmacy “Grigore T. Popa”, Iași, Romania

      B. Mihai

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    Corresponding author

    Correspondence to M. Moţa.

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    Funding source

    This work was supported by the Romanian Society of Diabetes, Nutrition and Metabolic Diseases, IHS Sofmedica, Abbott, Astra Zeneca, Novo Nordisk, MSD, Servier, Novartis, Worwag Pharma.

    Conflict of interest

    The authors declare that they have no conflict of interest. The sponsors had no role in the design of the study, in the execution, interpretation of the data or the decision to submit the results.

    Ethical approval

    All procedures performed in this study involving human participants were in accordance with the ethical standards of the Romanian National Ethics Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

    Informed consent

    Informed consent was obtained from all individual participants included in the study.

    Additional information

    Adina Popa and Eugen Moţa had equal contribution to this article.

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    Popa, S., Moţa, M., Popa, A. et al. Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study. J Endocrinol Invest 39, 1045–1053 (2016). https://doi.org/10.1007/s40618-016-0470-4

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