Journal of Endocrinological Investigation

, Volume 37, Issue 7, pp 661–666 | Cite as

Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes

  • Ernesto MaddaloniEmail author
  • Luca D’Onofrio
  • Angelo Lauria
  • Anna Rita Maurizi
  • Rocky Strollo
  • Andrea Palermo
  • Nicola Napoli
  • Silvia Angeletti
  • Paolo Pozzilli
  • Silvia Manfrini
Original Article



Diabetic osteopathy is an upcoming complication of diabetes characterized by osteoporosis, increased risk for bone fractures and alterations in bone metabolism. Osteocalcin (OC) is a bone-specific protein produced by osteoblasts involved in the regulation of glucose and energy metabolism. The aim of this study is to determine whether OC serum levels are correlated with metabolic control in adult subjects with type one diabetes mellitus (T1DM).


A cross-sectional study was conducted on 93 subjects (51 men) with mean age, disease duration and body mass index (BMI) of 39.9 ± 12.3, 17.2 ± 12.6 years and 24.5 ± 3.4 kg/m2, respectively. Blood samples were drawn to measure levels of hemoglobin A1c (HbA1c), OC, 25-OH vitamin D and PTH.


Significant inverse correlations were found between OC and HbA1c (r = −0.295, P = 0.004) and between OC and BMI (r = −0.218, P = 0.037). These correlations were confirmed also among men in the analyses by gender [HbA1c vs OC: r = −0.363, P = 0.009; BMI vs OC: r = −0.291, P = 0.043], and similar but nonsignificant trends were confirmed among women. A significant difference in mean OC was also found between the lowest and the highest HbA1c tertile (22.3 ± 10.0 vs 16.9 ± 8.0 ng/mL, P = 0.025).


These data show that in T1DM of long duration, OC serum levels are inversely associated with HbA1c and BMI, supporting the hypothesis that a poor glycemic control can affect osteoblast function.


Osteocalcin HbA1c BMI Type 1 diabetes 



This study was supported by a grant from the Italian Ministry of University and Technological research (Prin project of national interest).

Conflict of interest

All the authors declare no conflict of interest.


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Copyright information

© Italian Society of Endocrinology (SIE) 2014

Authors and Affiliations

  • Ernesto Maddaloni
    • 1
    Email author
  • Luca D’Onofrio
    • 1
  • Angelo Lauria
    • 1
  • Anna Rita Maurizi
    • 1
  • Rocky Strollo
    • 1
  • Andrea Palermo
    • 1
  • Nicola Napoli
    • 1
  • Silvia Angeletti
    • 3
  • Paolo Pozzilli
    • 1
    • 2
  • Silvia Manfrini
    • 1
  1. 1.Department Endocrinology and DiabetesUniversity Campus Bio-Medico of RomeRomeItaly
  2. 2.Centre for Diabetes, Barts and The London School of MedicineQueen Mary University of LondonLondonUK
  3. 3.Medical Laboratory UnitUniversity Campus Bio-Medico of RomeRomeItaly

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