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Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release
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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

17 October 2022

Xiaowei Mao, Kexin Chen, … Hongyu Zhang

Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

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  • Research Article
  • Open Access
  • Published: 03 June 2022

Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release

  • Qiangbing Wei1,
  • Tian Fu1,2,
  • Lele Lei1,
  • Huan Liu1,2,
  • Yixin Zhang1,
  • Shuanhong Ma2,3 &
  • …
  • Feng Zhou2 

Friction volume 11, pages 410–424 (2023)Cite this article

  • 604 Accesses

  • Metrics details

Abstract

Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA—PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA—PSPMA). The as-prepared h-SiO2/PDA—PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA—PSPMA coating and “rolling” effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA—PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA—PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.

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Acknowledgements

This work was financially supported by National Natural Science Foundation of China (52065061, 22032006), Outstanding Youth Fund of Gansu Province (21JR7RA158, 21JR7RA095), Innovation Fund for Universities of Gansu Province (2021A-015), and Youth Innovation Promotion Association CAS (2019411).

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Authors and Affiliations

  1. Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China

    Qiangbing Wei, Tian Fu, Lele Lei, Huan Liu & Yixin Zhang

  2. State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China

    Tian Fu, Huan Liu, Shuanhong Ma & Feng Zhou

  3. Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai, 264006, China

    Shuanhong Ma

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  1. Qiangbing Wei
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  2. Tian Fu
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Correspondence to Qiangbing Wei or Shuanhong Ma.

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Qiangbing WEI. He received his Ph.D. degree from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences in 2014. Then, he joined the School of Chemistry and Chemical Engineering, Northwest Normal University (NWNU) and currently is an associate professor. He did postdoctoral research in Matyjaszewski Polymer Group at Carnegie Mellon University from 2018 to 2020. His research interests include controlled radical polymerization, polymer-based materials for biomimetic lubrication and antibacterial applications, and polymer-liquid metal soft nanocomposites for flexible and wearable sensors.

Shuanhong MA. He received his Ph.D. degree from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences in 2016. Then, he joined the State Key Laboratory of Solid Lubrication and currently is an associate professor. He published more than 45 papers as the first or corresponding author in Nature Communications, Matter, Advanced Materials, Angewandte Chemie International Edition, Advanced Functional Materials, Chemistry of Materials, Advanced Science, Small, Friction, et al. His papers have been cited nearly 2,000 times. He has applied for 30 patents and 16 of them have been authorized. His research interests include surface lubrication modification, high performance water lubricating materials, soft matter mechanics, and the mechanism between interface contact and lubrication.

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Wei, Q., Fu, T., Lei, L. et al. Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release. Friction 11, 410–424 (2023). https://doi.org/10.1007/s40544-022-0605-x

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  • Received: 28 September 2021

  • Revised: 21 December 2021

  • Accepted: 31 January 2022

  • Published: 03 June 2022

  • Issue Date: March 2023

  • DOI: https://doi.org/10.1007/s40544-022-0605-x

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Keywords

  • osteoarthritis treatment
  • functionalized nanoparticles
  • injectable biolubricant
  • friction reduction
  • drug release
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