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Pharmacogenomics as a Tool for Management of Drug Hypersensitivity Reactions

  • Drug Allergy (L Mayorga, Section Editor)
  • Published:
Current Treatment Options in Allergy Aims and scope Submit manuscript

Abstract

Purpose of review

Drug hypersensitivity reactions constitute an unpredictable, serious problem for health care systems as they interfere with drug treatment, limit therapeutic options, and may be life-threatening. In addition to specific patient factors, they are also influenced by a genetic component. Indeed, a considerable body of knowledge supports the participation of genetic variants in their underlying mechanisms.

Recent findings

Latest research on this topic confirms the involvement of specific HLA alleles in non-immediate reactions. Two well-known examples are the HLA-B*58:01 allele in severe allopurinol-triggered reactions, and the HLA-B*15:02 allele in carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. However, there is a lack of reliable genetic markers for immediate reactions and for hypersensitivity to NSAIDs.

Summary

We summarize available information on the genetics of drug hypersensitivity reactions, highlighting regulatory agencies recommendations when available. We include some comments about new technological tools that should be implemented in the study of these reactions.

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Acknowledgements

We thank Ms. Claudia Corazza for her help with the English version of the manuscript.

Funding

This work was supported by grants co-funded by the European Regional Development Fund (ERDF), from the Carlos III National Health Institute (ARADyAL network RD16/0006/0001, RD16/0006/0007, RD16/0006/00018, and RD16/0006/00019; and PI17/01593). I Doña is a researcher from the Juan Rodés Program (Ref JR15/0036), N Pérez-Sanchez from the Rio Hortega Program (Ref CM17/00141, respectively), and JA Cornejo-García from the Miguel Servet Program (Ref CP14/00034), all from the Carlos III National Health Institute, Spanish Ministry of Economy and Competitiveness).

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Authors and Affiliations

  1. Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain

    Natalia Pérez-Sánchez MD, Inmaculada Doña MD PhD & María José Torres MD PhD

  2. Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Plaza del Hospital Civil s/n, Hospital Civil, Pabellón 6, 1ª planta, 29009, Málaga, Spain

    Raquel Jurado-Escobar BSc & José Antonio Cornejo-García PhD

  3. ARADyAL Network RD16/0006/0001, Carlos III Health Institute, Malaga, Spain

    Inmaculada Doña MD PhD, María José Torres MD PhD & José Antonio Cornejo-García PhD

  4. Hospital General Universitario de Alicante, Alicante, Spain

    Víctor Soriano-Gomis Md PhD

  5. ARADyAL Network RD16/0006/0032, Carlos III Health Institute, Alicante, Spain

    Víctor Soriano-Gomis Md PhD

  6. Allergy Service, Reina Sofia University Hospital, Cordoba, Spain

    Carmen Moreno-Aguilar MD PhD

  7. Maimonides Institute for Research in Biomedicine (IMIBIC), Cordoba, Spain

    Carmen Moreno-Aguilar MD PhD

  8. ARADyAL Network RD16/0006/0018, Carlos III Health Institute, Cordoba, Spain

    Carmen Moreno-Aguilar MD PhD

  9. Allergy Section, Pneumology Department, Hospital Clínic Universitat de Barcelona, Barcelona, Spain

    Joan Bartra MD PhD

  10. ARADyAL Network RD16/0006/0007, Carlos III Health Institute, Barcelona, Spain

    Joan Bartra MD PhD

  11. Biosciences Institute of Salamanca, University of Salamanca, Salamanca, Spain

    María Isidoro-García MD PhD

  12. Department of Medicine, University of Salamanca, Salamanca, Spain

    María Isidoro-García MD PhD

  13. ARADyAL Network RD16/0006/0019, Carlos III Health Institute, Salamanca, Spain

    María Isidoro-García MD PhD

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  1. Natalia Pérez-Sánchez MD
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Correspondence to José Antonio Cornejo-García PhD.

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Natalia Pérez-Sánchez declares that she has no conflict of interest. Raquel Jurado-Escobar declares that she has no conflict of interest. Inmaculada Doña declares that she has no conflict of interest. Víctor Soriano-Gomís declares that he has no conflict of interest. Carmen Moreno-Aguilar declares that she has no conflict of interest. Joan Bartra declares that she has no conflict of interest. María Isidoro-García declares that she has no conflict of interest. María José Torres declares that she has no conflict of interest. José Antonio Cornejo-García declares that he has no conflict of interest.

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Pérez-Sánchez, N., Jurado-Escobar, R., Doña, I. et al. Pharmacogenomics as a Tool for Management of Drug Hypersensitivity Reactions. Curr Treat Options Allergy 6, 1–17 (2019). https://doi.org/10.1007/s40521-019-0199-3

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