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Geographical Variations in Food Protein-Induced Enterocolitis Syndrome

  • Food Allergy (M Fernandez-Rivas, Section Editor)
  • Published:
Current Treatment Options in Allergy Aims and scope Submit manuscript

Abstract

Purpose of Review

Food protein-induced enterocolitis syndrome (FPIES) is considered a rare, non-IgE-mediated food allergy that typically presents in infancy. As there is not a specific biological marker of the disease, diagnosis of FPIES is based on typical symptoms that improve once the offending food is removed from the diet. The most common causative foods are cow’s milk, soy, and rice. For years, we have thought that the typical symptoms and the triggering foods were the same around the world.

Recent Findings

The epidemiological data are scarce and variable but recent studies suggests that FPIES is not as rare as it is thought but rather misdiagnosed. The clinical symptoms and the offending foods vary depending on the geographic area. Perhaps because different phenotypes might exist due to dietary habits, race, or ethnicity.

Summary

FPIES symptoms and causative foods are not the same around the world. It is important to know our population in order to reach a correct and early diagnosis of our patients.

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References and Recommended Reading

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Authors and Affiliations

  1. Paediatric Allergy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Sonsoles Infante MD, PhD, Paula Cabrera-Freitag MD, PhD & Alberto Alvarez-Perea MD, PhD

  2. Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain

    Sonsoles Infante MD, PhD, Paula Cabrera-Freitag MD, PhD & Alberto Alvarez-Perea MD, PhD

  3. Allergy Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

    Cristina Morales-Cabeza MD

Authors
  1. Sonsoles Infante MD, PhD
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  2. Paula Cabrera-Freitag MD, PhD
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  3. Cristina Morales-Cabeza MD
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  4. Alberto Alvarez-Perea MD, PhD
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Correspondence to Sonsoles Infante MD, PhD.

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Sonsoles Infante declares that she has no conflict of interest. Paula Cabrera-Freitag declares that she has no conflict of interest. Cristina Morales-Cabeza declares that she has no conflict of interest. Alberto Alvarez-Perea declares that he has no conflict of interest.

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Infante, S., Cabrera-Freitag, P., Morales-Cabeza, C. et al. Geographical Variations in Food Protein-Induced Enterocolitis Syndrome. Curr Treat Options Allergy 6, 309–321 (2019). https://doi.org/10.1007/s40521-019-00234-x

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