Sicilian centenarian offspring are more resistant to immune ageing
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Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls.
To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls.
Analysis of Treg cells, γδ T cells, mucosal-associated invariant T cells, and senescent immune T cells was performed in centenarian offspring and controls.
We report significant differences between elderly and centenarian offspring in most of the studied subsets, showing that centenarian offspring subsets present an intermediate phenotyping between elderly and younger people.
The whole present data confirm and extend the previous results showing that centenarian offspring retain more youthful immunological parameters and that the exhaustion of the immune system is less evident than in elderly without centenarian parents, though further investigations are warranted.
KeywordsAgeing Centenarians Immune senescence Inflammation Flow cytometry
The authors are grateful to all participants (as well as their legal proxies) for their great contributions.
This work was supported by Grant of Ministry of University (PRIN: progetti di ricerca di rilevante interesse nazionale—Bando 2015 Prot 20157ATSLF) “Discovery of molecular and genetic/epigenetic signatures underlying resistance to age-related diseases and comorbidities” to CC and GC. MB, AA, and GA are fellows of this project.
Compliance with ethical standards
Conflict of interest
None of the authors has any conflict of interest related.
Human and animal rights
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any study with animals performed by any of the authors.
Informed consent was obtained from all the participants in this study or their legal proxies.
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