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Characteristics of advanced gastric cancer with negative or only perigastric lymph node metastasis in elderly patients

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Abstract

Objectives

After gastrectomy with extended lymph node (LN) dissection, the damage of celiac plexus seems to cause of disorder of eating habits. To clarify the indication of gastrectomy with limited LN dissection for elderly patients, the pathological characteristics of advanced gastric cancer in elderly patients were examined in this study.

Methods

Forty-seven patients aged ≥80 years with advanced gastric cancer (deeper than pT2) who underwent curative gastrectomy from 1998 to 2015 were enrolled. Patients were classified into two groups by extent of LN metastasis: Group A, with N0 or only perigastric LN metastasis (n = 33); Group B, LN metastasis beyond the perigastric area (n = 14). Pathological factors were then evaluated.

Results

No significant differences were observed in age, sex, body mass index, American Society of Anesthesiologists physical status classification, serum level of carcinoembryonic antigen, surgical procedure, extent of LN dissection, and number of dissected LNs. Pathological findings showed no significant differences in tumor location, macroscopic type, histologic type, and lymphovascular invasion. However, significant differences were observed in tumor maximum diameter at the cut-off level of 40 mm (Group A: ≤40 mm, n = 10 and >40 mm, n = 23; Group B: ≤40 mm, n = 0 and >40 mm, n = 14; P = 0.02).

Conclusion

In the elderly patients, LN metastasis in advanced gastric cancer of ≤40 mm in diameter was limited to be within the perigastric area. Gastrectomy with only perigastric LN dissection may be adopted in these patients.

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Author information

Authors and Affiliations

  1. Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, 1-1, Idaigaoka, Hasama-mach, Oita, 879-5593, Japan

    Hajime Fujishima, Takao Hara, Michihiro Ichimanda, Yuki Shitomi, Hidefumi Shiroshita, Tsuyoshi Etoh & Masafumi Inomata

  2. Center for Community Medicine, Oita University Faculty of Medicine, 1-1, Idaigaoka, Hasama-mach, Oita, 879-5593, Japan

    Yoshitake Ueda & Norio Shiraishi

Authors
  1. Hajime Fujishima
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  2. Yoshitake Ueda
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  3. Norio Shiraishi
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  4. Takao Hara
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  7. Hidefumi Shiroshita
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  8. Tsuyoshi Etoh
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  9. Masafumi Inomata
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Contributions

Study concept and design: FH, UY, and SN. Data acquisition: HT, IM, and SY. Quality control of data and algorithms: FH. Data analysis and interpretation: SH and ET. Manuscript preparation and editing: FH, UY, and SN. Manuscript review: SN and IM.

Corresponding author

Correspondence to Yoshitake Ueda.

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Conflict of interest

All authors disclose no conflicts of interest relevant to this study. This study did not receive any funding from any sources.

Funding

This study did not receive any funding from any sources.

Ethical approval

This study was approved by the Ethical Committee of Oita University Faculty of Medicine.

Informed consent

All patients included in the study gave their written informed consent.

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Fujishima, H., Ueda, Y., Shiraishi, N. et al. Characteristics of advanced gastric cancer with negative or only perigastric lymph node metastasis in elderly patients. Aging Clin Exp Res 30, 161–168 (2018). https://doi.org/10.1007/s40520-017-0767-y

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  • DOI: https://doi.org/10.1007/s40520-017-0767-y

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