Aging Clinical and Experimental Research

, Volume 30, Issue 2, pp 221–223 | Cite as

Telomerase activation and human health-span: an open issue

  • Virginia Boccardi
  • Patrizia Mecocci
Point of View

Aging is a natural process characterized by the progressive decline in physiological functions, which leads to increased vulnerability to diseases and death. The old age population is increasing worldwide thanks to lengthen of life expectancy at birth, defined as the average total number of years that a human expects to live. However, while life expectancy is still rising, parameters of health-span have stagnated for years. Thus, the prevalence of age-related diseases, including neurodegenerative, cardiovascular and metabolic diseases, continues to growth with a significant negative impact on health and care systems.

“Every man desired to live long but no man would be old”, said Jonathan Swift in the seventeenth century and despite many efforts in research and the large amount of described theories, we are still unable to identify hallmark of aging and far from the identification of the exact mechanisms underlying human aging. Numerous and complex are the mechanisms involved in the...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Medicine, Institute of Gerontology and GeriatricsUniversity of PerugiaPerugiaItaly

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