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Combined use of the multidimensional prognostic index (MPI) and procalcitonin serum levels in predicting 1-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP): a prospective study

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Abstract

Background

Several scores and biomarkers, i.e., procalcitonin (PCT), were proposed to stratify the mortality risk in community-acquired pneumonia (CAP).

Aim

Evaluating prognostic accuracy of PCT and Multidimensional Prognostic Index (MPI) for 1-month mortality risk in older patients with CAP.

Methods

At hospital admission and at discharge, patients were evaluated by a Comprehensive Geriatric Assessment to calculate MPI. Serum PCT was measured at admission and 1, 3, and 5 days after hospital admission.

Results

49 patients were enrolled. The overall 1-month mortality was 44.5 for 100-persons year. Mortality rates were higher with the increasing of MPI. In survived patients, MPI at discharge showed higher predictive accuracy than MPI at admission. Adding PCT levels to admission MPI prognostic accuracy for 1-month mortality significantly increased.

Conclusion

In older patients with CAP, MPI significantly predicted 1 month mortality. PCT levels significantly improved the accuracy of MPI at admission in predicting 1-month mortality.

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Authors and Affiliations

  1. Department of Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, National Relevance & High Specialization Hospital, Mura delle Cappuccine 14, Genova, 16128, Italy

    Alberto Pilotto, Simone Dini & Alberto Cella

  2. Geriatrics unit, Azienda ULSS 16, Padova, Italy

    Julia Daragjati & Mario Lo Storto

  3. Department of Laboratory Medicine, Azienda ULSS 16 and Azienda Ospedaliera, Padova, Italy

    Manuela Miolo, Monica Maria Mion, Martina Zaninotto, Paolo Carraro & Mario Plebani

  4. IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

    Andrea Fontana, Filomena Addante & Massimiliano Copetti

Authors
  1. Alberto Pilotto
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  2. Simone Dini
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  3. Julia Daragjati
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  4. Manuela Miolo
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  5. Monica Maria Mion
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  6. Andrea Fontana
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  7. Mario Lo Storto
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  8. Martina Zaninotto
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  9. Alberto Cella
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  10. Paolo Carraro
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  11. Filomena Addante
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  12. Massimiliano Copetti
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  13. Mario Plebani
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Corresponding author

Correspondence to Alberto Pilotto.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Pilotto, A., Dini, S., Daragjati, J. et al. Combined use of the multidimensional prognostic index (MPI) and procalcitonin serum levels in predicting 1-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP): a prospective study. Aging Clin Exp Res 30, 193–197 (2018). https://doi.org/10.1007/s40520-017-0759-y

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  • DOI: https://doi.org/10.1007/s40520-017-0759-y

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