Abstract
Purpose
To gain further understanding of the general medical comorbidity of binge eating disorder (BED) beyond its association with obesity.
Method
We reviewed studies of general medical comorbidity in people with BED or clinically significant binge eating behavior beyond obesity. We also reviewed studies of BED in specific medical conditions.
Results
Three broad study categories of medical comorbidity in BED were found: cross-sectional studies of medical conditions in BED; prospective studies of medical conditions in BED; and studies of BED in specific medical conditions. Cross-sectional epidemiologic data suggest that BED is associated with medical conditions related to obesity, including diabetes, hypertension, dyslipidemias, sleep problems/disorders, and pain conditions, and that BED may be related to these conditions independent of obesity and co-occurring psychiatric disorders. Prospective data suggest that BED may be associated with type 2 diabetes and metabolic syndrome. BED or binge eating behavior is also associated with asthma and gastrointestinal symptoms and disorders, and among women, menstrual dysfunction, pregnancy complications, intracranial hypertension, and polycystic ovary syndrome.
Conclusions
BED is associated with substantial medical comorbidity beyond obesity. Further study of the general medical comorbidity of BED and its relationship to obesity and co-occurring psychiatric disorders is greatly needed.
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Drs. Olguin, Fuentes and Gabler have no conflicts of interest to disclose. Dr. McElroy is a consultant to or member of the scientific advisory boards of Bracket, F. Hoffmann-La Roche Ltd., MedAvante, Myriad, Naurex, Novo Nordisk, Shire, and Sunovion. She is a principal or co-investigator on studies sponsored by the Alkermes, Forest, Marriott Foundation, National Institute of Mental Health, Naurex, Orexigen Therapeutics, Inc., Shire, Sunovion, and Takeda Pharmaceutical Company Ltd. She is also an inventor on United States Patent No. 6,323,236 B2, Use of Sulfamate Derivatives for Treating Impulse Control Disorders, and along with the patent’s assignee, the University of Cincinnati, Cincinnati, Ohio, has received payments from Johnson & Johnson, which has exclusive rights under the patent. Dr. Keck is employed by the University of Cincinnati College of Medicine and the University of Cincinnati Physicians. Dr. Keck is presently or has been in the past year a principal or co-investigator on research studies sponsored by: Cephalon, Marriott Foundation, National Institute of Mental Health (NIMH), Shire. Dr. Keck has been reimbursed for consulting to: 2014: Shire, Supernus, Otsuka, ProPhase, Merck. Dr. Paul E. Keck, Jr. is a co-inventor on United States Patent No. 6,387,956: Shapira NA, Goldsmith TD, Keck, PE Jr. (University of Cincinnati) Methods of treating obsessive–compulsive spectrum disorder comprises the step of administering an effective amount of tramadol to an individual. Filed March 25, 1999; approved May 14, 2002. Dr. Keck has received no financial gain from this patent. Dr. Guerdjikova is employed by the University of Cincinnati College of Medicine and is a consultant for Bracket.
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Olguin, P., Fuentes, M., Gabler, G. et al. Medical comorbidity of binge eating disorder. Eat Weight Disord 22, 13–26 (2017). https://doi.org/10.1007/s40519-016-0313-5
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DOI: https://doi.org/10.1007/s40519-016-0313-5